Bedeutung des zirkadianen Schlafrhythmus für den Energiestoffwechsel

Translated title of the contribution: Importance of sleep and circadian rhythm for energy metabolism

S. Meyhöfer, B. Wilms, H. Oster, S. M. Schmid*

*Corresponding author for this work


The circadian clock is a complex and highly specialized network of the human organism and is key for metabolic health. Circadian rhythms are modulated by behavioral patterns, physical activity, food intake as well as sleep loss and sleep disorders. Furthermore, an altered expression of clock genes (e. g. PERIOD1 and 2) can alter circadian rhythms. Chronodisruption, i. e. the alteration of circadian rhythms, is associated with a variety of mental and physical illnesses. Recent studies show a significant association between quantitative and qualitative sleep rhythm disturbances and an increasing prevalence of obesity. Furthermore, reduced sleep quality and duration lead to decreased glucose tolerance and insulin sensitivity, thus increasing the risk of developing type 2 diabetes. In addition to the core components of the metabolic syndrome, there are also changes in hormonal and neuronal signaling pathways impinging on human energy metabolism. This review provides an overview of the current literature highlighting the close link between circadian rhythms and human energy metabolism.

Translated title of the contributionImportance of sleep and circadian rhythm for energy metabolism
Original languageGerman
Issue number2
Pages (from-to)122–127
Number of pages6
Publication statusPublished - 2019

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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