Abstract
Serum BDNF concentrations in 2053 participants of the Berlin Aging Study II (BASE-II; 1572 individuals from the older age group [60–85 years], 481 individuals from the younger-age reference group [22–37 years]) were studied. There was no effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations. Multiple linear regression analysis failed to detect significant relationships of Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score to BDNF levels. However, we detected a positive correlation between platelet counts and BDNF levels (r = 0.303, p < 0.001). Our findings do not support an effect of aging, self-reported depression, or the Val66Met variant on serum BDNF concentrations. The role of thrombocytes in the biology of serum BDNF merits further study.
| Original language | English |
|---|---|
| Journal | Neurobiology of Aging |
| Volume | 101 |
| Pages (from-to) | 221-223 |
| Number of pages | 3 |
| ISSN | 0197-4580 |
| DOIs | |
| Publication status | Published - 05.2021 |
Funding
The BASE-II research project (Co-PIs are Lars Bertram, Ilja Demuth, Denis Gerstorf, Ulman Lindenberger, Graham Pawelec, Elisabeth Steinhagen-Thiessen, and Gert G Wagner) is supported by the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) under grant numbers 16SV5536K, 16SV5537, 16SV5538, 16SV5837, 01UW0808, 01GL1716A, and 01GL1716B. Another source of funding is the Max Planck Institute for Human Development, Berlin, Germany. Additional contributions (e.g. equipment, logistics, and personnel) are made from each of the other participating sites. This work was supported by the Deutsche Forschungsgemeinschaft (Exc257 to M.E.; KR 2956/4-1 to G.K.; GE 2576/2-1 to K.G.), the Bundesministerium für Bildung und Forschung (CSB to M.E. K.G. and G.K.), the van Geest Cardiovascular Development Fund (to G.K.), and the German Center for Neurodegenerative Diseases (DZNE to M.E.), the German Center for Cardiovascular Research (DZHK to M.E.), and the Corona Foundation (to M.E). The authors wish to thank Silvia Saft and Hannelore Stender for excellent technical assistance. The BASE-II research project (Co-PIs are Lars Bertram, Ilja Demuth, Denis Gerstorf, Ulman Lindenberger, Graham Pawelec, Elisabeth Steinhagen-Thiessen, and Gert G Wagner) is supported by the German Federal Ministry of Education and Research ( Bundesministerium für Bildung und Forschung , BMBF) under grant numbers 16SV5536K , 16SV5537 , 16SV5538 , 16SV5837 , 01UW0808 , 01GL1716A , and 01GL1716B . Another source of funding is the Max Planck Institute for Human Development , Berlin, Germany. Additional contributions (e.g., equipment, logistics, and personnel) are made from each of the other participating sites. This work was supported by the Deutsche Forschungsgemeinschaft ( Exc257 to M.E.; KR 2956/4-1 to G.K.; GE 2576/2-1 to K.G.), the Bundesministerium für Bildung und Forschung (CSB to M.E., K.G., and G.K.), the van Geest Cardiovascular Development Fund (to G.K.), and the German Center for Neurodegenerative Diseases (DZNE to M.E.), the German Center for Cardiovascular Research (DZHK to M.E.), and the Corona Foundation (to M.E). The authors wish to thank Silvia Saft and Hannelore Stender for excellent technical assistance.
