BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S. Karamohamed; J. C. Latourelle; B. A. Racette; J. S. Perlmutter; G. F. Wooten; M. Lew; C. Klein; H. Shill; L. I. Golbe; M. H. Mark; M. Guttman; G. Nicholson; J. B. Wilk; M. Saint-Hilaire; A. L. DeStefano; R. Prakash; S. Tobin; J. Williamson; O. Suchowersky; N. Labell; B. N.J. Growdon; C. Singer; R. Watts; S. Goldwurm; G. Pezzoli; K. B. Baker; M. L. Giroux; P. P. Pramstaller; D. J. Burn; P. Chinnery; S. Sherman; P. Vieregge; I. Litvan; J. F. Gusella; R. H. Myers; A. Parsian

doi:10.1212/01.wnl.0000187075.81589.fd

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S. Karamohamed, J. C. Latourelle, B. A. Racette, J. S. Perlmutter, G. F. Wooten, M. Lew, C. Klein, H. Shill, L. I. Golbe, M. H. Mark, M. Guttman, G. Nicholson, J. B. Wilk, M. Saint-Hilaire, A. L. DeStefano, R. Prakash, S. Tobin, J. Williamson, O. Suchowersky, N. LabellB. N.J. Growdon, C. Singer, R. Watts, S. Goldwurm, G. Pezzoli, K. B. Baker, M. L. Giroux, P. P. Pramstaller, D. J. Burn, P. Chinnery, S. Sherman, P. Vieregge, I. Litvan, J. F. Gusella, R. H. Myers, A. Parsian^*

^*Corresponding author for this work

Institute of Neurogenetics

46 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Original language	English
Journal	Neurology
Volume	65
Issue number	11
Pages (from-to)	1823-1825
Number of pages	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/01.wnl.0000187075.81589.fd
Publication status	Published - 01.12.2005

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Karamohamed, S., Latourelle, J. C., Racette, B. A., Perlmutter, J. S., Wooten, G. F., Lew, M., Klein, C., Shill, H., Golbe, L. I., Mark, M. H., Guttman, M., Nicholson, G., Wilk, J. B., Saint-Hilaire, M., DeStefano, A. L., Prakash, R., Tobin, S., Williamson, J., Suchowersky, O., ... Parsian, A. (2005). BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology, 65(11), 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd

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title = "BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study",

abstract = "Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.",

author = "S. Karamohamed and Latourelle, {J. C.} and Racette, {B. A.} and Perlmutter, {J. S.} and Wooten, {G. F.} and M. Lew and C. Klein and H. Shill and Golbe, {L. I.} and Mark, {M. H.} and M. Guttman and G. Nicholson and Wilk, {J. B.} and M. Saint-Hilaire and DeStefano, {A. L.} and R. Prakash and S. Tobin and J. Williamson and O. Suchowersky and N. Labell and Growdon, {B. N.J.} and C. Singer and R. Watts and S. Goldwurm and G. Pezzoli and Baker, {K. B.} and Giroux, {M. L.} and Pramstaller, {P. P.} and Burn, {D. J.} and P. Chinnery and S. Sherman and P. Vieregge and I. Litvan and Gusella, {J. F.} and Myers, {R. H.} and A. Parsian",

year = "2005",

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Karamohamed, S, Latourelle, JC, Racette, BA, Perlmutter, JS, Wooten, GF, Lew, M, Klein, C, Shill, H, Golbe, LI, Mark, MH, Guttman, M, Nicholson, G, Wilk, JB, Saint-Hilaire, M, DeStefano, AL, Prakash, R, Tobin, S, Williamson, J, Suchowersky, O, Labell, N, Growdon, BNJ, Singer, C, Watts, R, Goldwurm, S, Pezzoli, G, Baker, KB, Giroux, ML, Pramstaller, PP, Burn, DJ, Chinnery, P, Sherman, S, Vieregge, P, Litvan, I, Gusella, JF, Myers, RH & Parsian, A 2005, 'BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study', Neurology, vol. 65, no. 11, pp. 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd

TY - JOUR

T1 - BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

AU - Karamohamed, S.

AU - Latourelle, J. C.

AU - Racette, B. A.

AU - Perlmutter, J. S.

AU - Wooten, G. F.

AU - Lew, M.

AU - Klein, C.

AU - Shill, H.

AU - Golbe, L. I.

AU - Mark, M. H.

AU - Guttman, M.

AU - Nicholson, G.

AU - Wilk, J. B.

AU - Saint-Hilaire, M.

AU - DeStefano, A. L.

AU - Prakash, R.

AU - Tobin, S.

AU - Williamson, J.

AU - Suchowersky, O.

AU - Labell, N.

AU - Growdon, B. N.J.

AU - Singer, C.

AU - Watts, R.

AU - Goldwurm, S.

AU - Pezzoli, G.

AU - Baker, K. B.

AU - Giroux, M. L.

AU - Pramstaller, P. P.

AU - Burn, D. J.

AU - Chinnery, P.

AU - Sherman, S.

AU - Vieregge, P.

AU - Litvan, I.

AU - Gusella, J. F.

AU - Myers, R. H.

AU - Parsian, A.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

AB - Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

UR - http://www.scopus.com/inward/record.url?scp=33645077925&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0000187075.81589.fd

DO - 10.1212/01.wnl.0000187075.81589.fd

M3 - Journal articles

C2 - 16344533

AN - SCOPUS:33645077925

SN - 0028-3878

VL - 65

SP - 1823

EP - 1825

JO - Neurology

JF - Neurology

IS - 11

ER -

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

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