TY - JOUR
T1 - Barrier function and natural moisturizing factor levels after cumulative exposure to short-chain aliphatic alcohols and detergents: Results of occlusion-modified tandem repeated irritation test
AU - Angelova-Fischer, Irena
AU - Stilla, Tasja
AU - Kezic, Sanja
AU - Fischer, Tobias W.
AU - Zillikens, Detlef
PY - 2016/11
Y1 - 2016/11
N2 - Alcohol-based disinfectants and detergents are common workplace factors for irritant contact dermatitis (ICD). Though occlusion and water are relevant co-exposures, the tandem effects of occlusion and sequential exposure to alcohols and detergents have not been studied. We therefore investigated the combined effects of occlusion with water and repeated exposure to n-propanol and/or sodium lauryl sulphate (SLS) in an occlusion-modified tandem irritation test. The outcomes included visual scoring, measurement of erythema, transepidermal water loss, capacitance and natural moisturizing factor (NMF) levels. Occlusion abrogated the skin barrier function and significantly enhanced the irritant-induced barrier damaging effects. The NMF levels of all irritant-exposed fields decreased significantly compared with the nonexposed fields; occlusion enhanced the decrease in NMF. Although SLS exerted more pronounced effects on the measured parameters, the barrier function impairment and NMF decrease after exposure to n-propanol in workplace-relevant concentrations, found in the study, confirm the significance of short-chain aliphatic alcohols for occupational ICD.
AB - Alcohol-based disinfectants and detergents are common workplace factors for irritant contact dermatitis (ICD). Though occlusion and water are relevant co-exposures, the tandem effects of occlusion and sequential exposure to alcohols and detergents have not been studied. We therefore investigated the combined effects of occlusion with water and repeated exposure to n-propanol and/or sodium lauryl sulphate (SLS) in an occlusion-modified tandem irritation test. The outcomes included visual scoring, measurement of erythema, transepidermal water loss, capacitance and natural moisturizing factor (NMF) levels. Occlusion abrogated the skin barrier function and significantly enhanced the irritant-induced barrier damaging effects. The NMF levels of all irritant-exposed fields decreased significantly compared with the nonexposed fields; occlusion enhanced the decrease in NMF. Although SLS exerted more pronounced effects on the measured parameters, the barrier function impairment and NMF decrease after exposure to n-propanol in workplace-relevant concentrations, found in the study, confirm the significance of short-chain aliphatic alcohols for occupational ICD.
UR - http://www.scopus.com/inward/record.url?scp=84992756742&partnerID=8YFLogxK
U2 - 10.2340/00015555-2363
DO - 10.2340/00015555-2363
M3 - Journal articles
C2 - 26864715
AN - SCOPUS:84992756742
SN - 0001-5555
VL - 96
SP - 880
EP - 884
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 7
ER -