Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis

Matthias Tisch; Susanne Maier; Serena Preyer; Savvas Kourtidis; Goetz Lehnerdt; Sebastian Winterhoff; Carsten V. Dalchow; Friederike Mueller-Jenckel; Holger H. Sudhoff; Stefanie Schröder; Assen Koitschev; Peter Amrhein; Karl Ludwig Bruchhage; Anke Leichtle; Christian Güldner; Juergen Grulich-Henn; Katrin Jensen; Moritz Pohl; Peter K. Plinkert; Sara Euteneuer

doi:10.1097/MAO.0000000000002789

Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis

Matthias Tisch^*, Susanne Maier, Serena Preyer, Savvas Kourtidis, Goetz Lehnerdt, Sebastian Winterhoff, Carsten V. Dalchow, Friederike Mueller-Jenckel, Holger H. Sudhoff, Stefanie Schröder, Assen Koitschev, Peter Amrhein, Karl Ludwig Bruchhage, Anke Leichtle, Christian Güldner, Juergen Grulich-Henn, Katrin Jensen, Moritz Pohl, Peter K. Plinkert, Sara Euteneuer

^*Corresponding author for this work

Clinic of Otorhinolaryngology

11 Citations (Scopus)

Abstract

Objective:Generation of pilot data for planning of prospective BET-studies for treatment of dilatory Eustachian tube (ET) dysfunction in children.Study Design:Retrospective multicenter analysis.Setting:Nine ENT departments at tertiary care teaching hospitals.Patients:4-12-year-old children with chronic otitis media with effusion (COME) for more than 3 months or more than 3 episodes of acute otitis media during the last year, having failed standard surgical therapy at least once.Intervention:BET with or without paracentesis, ventilation tube insertion, or tympanoplasty.Main outcome measures:Tympanic membrane appearance, tympanometry, and hearing threshold.Results:Two hundred ninety-nine ETs of 167 children were treated. Mean age was 9.1 years (95% confidence interval [95% CI]: 8.7-9.4 yr). In 249 ears (83.3%), COME and/or retraction of the tympanic membrane were the indication for BET. Median hearing threshold was 20 dB HL (95% CI: 0-46 dB). One hundred fifty-five ears (51.8%, 95% CI: 46.1-57.4%) showed a tympanogram type B. Treatment consisted of BET without other interventions ("BET-only") in 70 children, 128 ears. Median length of follow-up for 158 (94.6%) children was 2.6 months (95% CI: 0.3-16.1 mo). After treatment, the tympanic membrane appeared normal in 196 ears (65.6%, 95% CI: 60.0-70.8%, p < 0.001). Median hearing threshold improved to 10 dB HL (95% CI: 0-45 dB, p < 0.001). Tympanograms shifted toward type A and C (type A: 39.1%, 95% CI: 33.7-44.7, p < 0.001). These improvements were also observed in subgroup analyses of "BET-only" treatment and the indication of "COME" respectively.Conclusion:BET is improving a variety of dilatory ET dysfunction-related ear diseases in children. This study provides detailed data for design and planning of prospective studies on BET in children.

Original language	English
Journal	Otology and Neurotology
Volume	41
Issue number	7
Pages (from-to)	e921-e933
ISSN	1531-7129
DOIs	https://doi.org/10.1097/MAO.0000000000002789
Publication status	Published - 01.08.2020

Funding

This research project was carried out without any specific internal or external funding support. M.T., S.P., S.K., S.W., G.L., C.V.D., H.H.S., S.S., P.A., K.L.B., A.L., C.G., J.G.H., and S.E. received reimbursements for travel expenses from the manufarcurer of the Eustachian tube balloon utilized in this study (Spiggle & Theis Medizintechnik, Overath, Germany). C.V.D., H.H.S., and S.E. received financial support for holding symposia from Spiggle & Theis Medizintechnik. In addition, C.V.D. received consulting fees, S.S. financial support for another clinical study, and H.H.S. grant support form Spiggle & Theis Medizintechnik. All other authors have indicated that they have no financial competing interests, or other relationships that might lead to bias relevant to this manuscript.

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MAO.0000000000002789

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Tisch, M., Maier, S., Preyer, S., Kourtidis, S., Lehnerdt, G., Winterhoff, S., Dalchow, C. V., Mueller-Jenckel, F., Sudhoff, H. H., Schröder, S., Koitschev, A., Amrhein, P., Bruchhage, K. L., Leichtle, A., Güldner, C., Grulich-Henn, J., Jensen, K., Pohl, M., Plinkert, P. K., & Euteneuer, S. (2020). Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis. Otology and Neurotology, 41(7), e921-e933. https://doi.org/10.1097/MAO.0000000000002789

@article{18f1ba80ea3f409d9921e3b853dc8531,

title = "Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis",

abstract = "Objective:Generation of pilot data for planning of prospective BET-studies for treatment of dilatory Eustachian tube (ET) dysfunction in children.Study Design:Retrospective multicenter analysis.Setting:Nine ENT departments at tertiary care teaching hospitals.Patients:4-12-year-old children with chronic otitis media with effusion (COME) for more than 3 months or more than 3 episodes of acute otitis media during the last year, having failed standard surgical therapy at least once.Intervention:BET with or without paracentesis, ventilation tube insertion, or tympanoplasty.Main outcome measures:Tympanic membrane appearance, tympanometry, and hearing threshold.Results:Two hundred ninety-nine ETs of 167 children were treated. Mean age was 9.1 years (95\% confidence interval [95\% CI]: 8.7-9.4 yr). In 249 ears (83.3\%), COME and/or retraction of the tympanic membrane were the indication for BET. Median hearing threshold was 20 dB HL (95\% CI: 0-46 dB). One hundred fifty-five ears (51.8\%, 95\% CI: 46.1-57.4\%) showed a tympanogram type B. Treatment consisted of BET without other interventions ({"}BET-only{"}) in 70 children, 128 ears. Median length of follow-up for 158 (94.6\%) children was 2.6 months (95\% CI: 0.3-16.1 mo). After treatment, the tympanic membrane appeared normal in 196 ears (65.6\%, 95\% CI: 60.0-70.8\%, p < 0.001). Median hearing threshold improved to 10 dB HL (95\% CI: 0-45 dB, p < 0.001). Tympanograms shifted toward type A and C (type A: 39.1\%, 95\% CI: 33.7-44.7, p < 0.001). These improvements were also observed in subgroup analyses of {"}BET-only{"} treatment and the indication of {"}COME{"} respectively.Conclusion:BET is improving a variety of dilatory ET dysfunction-related ear diseases in children. This study provides detailed data for design and planning of prospective studies on BET in children.",

author = "Matthias Tisch and Susanne Maier and Serena Preyer and Savvas Kourtidis and Goetz Lehnerdt and Sebastian Winterhoff and Dalchow, \{Carsten V.\} and Friederike Mueller-Jenckel and Sudhoff, \{Holger H.\} and Stefanie Schr{\"o}der and Assen Koitschev and Peter Amrhein and Bruchhage, \{Karl Ludwig\} and Anke Leichtle and Christian G{\"u}ldner and Juergen Grulich-Henn and Katrin Jensen and Moritz Pohl and Plinkert, \{Peter K.\} and Sara Euteneuer",

note = "Funding Information: This research project was carried out without any specific internal or external funding support. M.T., S.P., S.K., S.W., G.L., C.V.D., H.H.S., S.S., P.A., K.L.B., A.L., C.G., J.G.H., and S.E. received reimbursements for travel expenses from the manufarcurer of the Eustachian tube balloon utilized in this study (Spiggle \& Theis Medizintechnik, Overath, Germany). C.V.D., H.H.S., and S.E. received financial support for holding symposia from Spiggle \& Theis Medizintechnik. In addition, C.V.D. received consulting fees, S.S. financial support for another clinical study, and H.H.S. grant support form Spiggle \& Theis Medizintechnik. All other authors have indicated that they have no financial competing interests, or other relationships that might lead to bias relevant to this manuscript. Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = aug,

day = "1",

doi = "10.1097/MAO.0000000000002789",

language = "English",

volume = "41",

pages = "e921--e933",

journal = "Otology and Neurotology",

issn = "1531-7129",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

Tisch, M, Maier, S, Preyer, S, Kourtidis, S, Lehnerdt, G, Winterhoff, S, Dalchow, CV, Mueller-Jenckel, F, Sudhoff, HH, Schröder, S, Koitschev, A, Amrhein, P, Bruchhage, KL , Leichtle, A, Güldner, C, Grulich-Henn, J, Jensen, K, Pohl, M, Plinkert, PK & Euteneuer, S 2020, 'Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis', Otology and Neurotology, vol. 41, no. 7, pp. e921-e933. https://doi.org/10.1097/MAO.0000000000002789

TY - JOUR

T1 - Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis

AU - Tisch, Matthias

AU - Maier, Susanne

AU - Preyer, Serena

AU - Kourtidis, Savvas

AU - Lehnerdt, Goetz

AU - Winterhoff, Sebastian

AU - Dalchow, Carsten V.

AU - Mueller-Jenckel, Friederike

AU - Sudhoff, Holger H.

AU - Schröder, Stefanie

AU - Koitschev, Assen

AU - Amrhein, Peter

AU - Bruchhage, Karl Ludwig

AU - Leichtle, Anke

AU - Güldner, Christian

AU - Grulich-Henn, Juergen

AU - Jensen, Katrin

AU - Pohl, Moritz

AU - Plinkert, Peter K.

AU - Euteneuer, Sara

N1 - Funding Information: This research project was carried out without any specific internal or external funding support. M.T., S.P., S.K., S.W., G.L., C.V.D., H.H.S., S.S., P.A., K.L.B., A.L., C.G., J.G.H., and S.E. received reimbursements for travel expenses from the manufarcurer of the Eustachian tube balloon utilized in this study (Spiggle & Theis Medizintechnik, Overath, Germany). C.V.D., H.H.S., and S.E. received financial support for holding symposia from Spiggle & Theis Medizintechnik. In addition, C.V.D. received consulting fees, S.S. financial support for another clinical study, and H.H.S. grant support form Spiggle & Theis Medizintechnik. All other authors have indicated that they have no financial competing interests, or other relationships that might lead to bias relevant to this manuscript. Publisher Copyright: © 2020 Lippincott Williams and Wilkins. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Objective:Generation of pilot data for planning of prospective BET-studies for treatment of dilatory Eustachian tube (ET) dysfunction in children.Study Design:Retrospective multicenter analysis.Setting:Nine ENT departments at tertiary care teaching hospitals.Patients:4-12-year-old children with chronic otitis media with effusion (COME) for more than 3 months or more than 3 episodes of acute otitis media during the last year, having failed standard surgical therapy at least once.Intervention:BET with or without paracentesis, ventilation tube insertion, or tympanoplasty.Main outcome measures:Tympanic membrane appearance, tympanometry, and hearing threshold.Results:Two hundred ninety-nine ETs of 167 children were treated. Mean age was 9.1 years (95% confidence interval [95% CI]: 8.7-9.4 yr). In 249 ears (83.3%), COME and/or retraction of the tympanic membrane were the indication for BET. Median hearing threshold was 20 dB HL (95% CI: 0-46 dB). One hundred fifty-five ears (51.8%, 95% CI: 46.1-57.4%) showed a tympanogram type B. Treatment consisted of BET without other interventions ("BET-only") in 70 children, 128 ears. Median length of follow-up for 158 (94.6%) children was 2.6 months (95% CI: 0.3-16.1 mo). After treatment, the tympanic membrane appeared normal in 196 ears (65.6%, 95% CI: 60.0-70.8%, p < 0.001). Median hearing threshold improved to 10 dB HL (95% CI: 0-45 dB, p < 0.001). Tympanograms shifted toward type A and C (type A: 39.1%, 95% CI: 33.7-44.7, p < 0.001). These improvements were also observed in subgroup analyses of "BET-only" treatment and the indication of "COME" respectively.Conclusion:BET is improving a variety of dilatory ET dysfunction-related ear diseases in children. This study provides detailed data for design and planning of prospective studies on BET in children.

AB - Objective:Generation of pilot data for planning of prospective BET-studies for treatment of dilatory Eustachian tube (ET) dysfunction in children.Study Design:Retrospective multicenter analysis.Setting:Nine ENT departments at tertiary care teaching hospitals.Patients:4-12-year-old children with chronic otitis media with effusion (COME) for more than 3 months or more than 3 episodes of acute otitis media during the last year, having failed standard surgical therapy at least once.Intervention:BET with or without paracentesis, ventilation tube insertion, or tympanoplasty.Main outcome measures:Tympanic membrane appearance, tympanometry, and hearing threshold.Results:Two hundred ninety-nine ETs of 167 children were treated. Mean age was 9.1 years (95% confidence interval [95% CI]: 8.7-9.4 yr). In 249 ears (83.3%), COME and/or retraction of the tympanic membrane were the indication for BET. Median hearing threshold was 20 dB HL (95% CI: 0-46 dB). One hundred fifty-five ears (51.8%, 95% CI: 46.1-57.4%) showed a tympanogram type B. Treatment consisted of BET without other interventions ("BET-only") in 70 children, 128 ears. Median length of follow-up for 158 (94.6%) children was 2.6 months (95% CI: 0.3-16.1 mo). After treatment, the tympanic membrane appeared normal in 196 ears (65.6%, 95% CI: 60.0-70.8%, p < 0.001). Median hearing threshold improved to 10 dB HL (95% CI: 0-45 dB, p < 0.001). Tympanograms shifted toward type A and C (type A: 39.1%, 95% CI: 33.7-44.7, p < 0.001). These improvements were also observed in subgroup analyses of "BET-only" treatment and the indication of "COME" respectively.Conclusion:BET is improving a variety of dilatory ET dysfunction-related ear diseases in children. This study provides detailed data for design and planning of prospective studies on BET in children.

UR - https://www.scopus.com/pages/publications/85088485261

U2 - 10.1097/MAO.0000000000002789

DO - 10.1097/MAO.0000000000002789

M3 - Journal articles

C2 - 32658110

AN - SCOPUS:85088485261

SN - 1531-7129

VL - 41

SP - e921-e933

JO - Otology and Neurotology

JF - Otology and Neurotology

IS - 7

ER -

Balloon Eustachian Tuboplasty (BET) in Children: A Retrospective Multicenter Analysis

Abstract

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UN SDGs

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