Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Philipp H. Reichel; Christine Seemann; Elena Csernok; Jens M. Schröder; Antje Müller; Wolfgang L. Gross; Hendrik Schultz

doi:10.1128/CDLI.10.3.473-475.2003

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Philipp H. Reichel, Christine Seemann, Elena Csernok^*, Jens M. Schröder, Antje Müller, Wolfgang L. Gross, Hendrik Schultz

^*Corresponding author for this work

Clinic of Rheumatology

University of Kiel

24 Citations (Scopus)

Abstract

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.

Original language	English
Journal	Clinical and Diagnostic Laboratory Immunology
Volume	10
Issue number	3
Pages (from-to)	473-475
Number of pages	3
ISSN	1071-412X
DOIs	https://doi.org/10.1128/CDLI.10.3.473-475.2003
Publication status	Published - 06.2003

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1128/CDLI.10.3.473-475.2003

Cite this

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abstract = "The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.",

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AU - Reichel, Philipp H.

AU - Seemann, Christine

AU - Csernok, Elena

AU - Schröder, Jens M.

AU - Müller, Antje

AU - Gross, Wolfgang L.

AU - Schultz, Hendrik

PY - 2003/6

Y1 - 2003/6

N2 - The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.

AB - The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.

UR - https://www.scopus.com/pages/publications/0037618998

U2 - 10.1128/CDLI.10.3.473-475.2003

DO - 10.1128/CDLI.10.3.473-475.2003

M3 - Journal articles

C2 - 12738651

AN - SCOPUS:0037618998

SN - 1071-412X

VL - 10

SP - 473

EP - 475

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

IS - 3

ER -

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Abstract

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