Bacterial modulators of bone remodeling in the periodontal pocket

Brian Henderson, Frank Kaiser

12 Citations (Scopus)


The signaling network involved in the pathogenesis of periodontal disease is not yet fully understood. This review aims to describe possible mechanisms through which the bacterial modulators may be linked directly or indirectly to the process of alveolar bone loss in periodontitis. From the late 1970s to present, new paradigm shifts have been developed regarding our understanding of pathological bone remodeling in periodontal disease. Upcoming evidence suggests that in periodontal disease the local immune response is exacerbated and involves the existence of signaling pathways that have been shown to modulate bone-cell function leading to alveolar bone loss. Those complex signaling pathways have been observed not only between bacteria but also between bacteria and the gingival surface of the host. More specifically, it has been shown that bacteria, through their secretion molecules, may interact indirectly and directly with immune-type cells of the host, resulting in the production of osteolytic agents that enhance bone resorption. Further research is required to provide a clear understanding of the role of these molecules in the pathogenesis of periodontal disease, and the availability of new technologies, such as next-generation sequencing and metagenomic analysis, may be useful tools in achieving this.

Original languageEnglish
JournalPeriodontology 2000
Issue number1
Pages (from-to)97-108
Number of pages12
Publication statusPublished - 2018

Research Areas and Centers

  • Research Area: Medical Genetics


Dive into the research topics of 'Bacterial modulators of bone remodeling in the periodontal pocket'. Together they form a unique fingerprint.

Cite this