B-Symptomatik bei unklarer mediastinaler Lymphadenopathie: Fallbericht eines 72-jährigen Patienten mit VEXAS-Syndrom

A. Ripke; A. Münchau; N. von Bubnoff; S. Jendrek; S. Kopelke; C. Kümpers; P. Parschke; S. Schinke; C. Khandanpour

doi:10.1007/s00108-023-01543-9

B-Symptomatik bei unklarer mediastinaler Lymphadenopathie: Fallbericht eines 72-jährigen Patienten mit VEXAS-Syndrom

Translated title of the contribution: B symptoms in unexplained mediastinal lymphadenopathy: Case report of a 72-year-old male patient with VEXAS syndrome

A. Ripke^*, A. Münchau, N. von Bubnoff, S. Jendrek, S. Kopelke, C. Kümpers, P. Parschke, S. Schinke, C. Khandanpour

^*Corresponding author for this work

Abstract

The case of a 72-year-old male patient who presented to our centre for rare diseases with recurrent fever, night sweats and weight loss with initially confirmed mediastinal lymphadenopathy is reported. Investigation of lymph node material was unrevealing. As an additional finding, the patient had a myelodysplastic syndrome. VEXAS syndrome (vacuoles, E1 enzyme, X‑linked, autoinflammatory, somatic) could be confirmed on the basis of a bone marrow biopsy and genetic testing.

Translated title of the contribution	B symptoms in unexplained mediastinal lymphadenopathy: Case report of a 72-year-old male patient with VEXAS syndrome
Original language	German
Journal	Innere Medizin (Germany)
Volume	64
Issue number	8
Pages (from-to)	810-814
Number of pages	5
ISSN	2731-7080
DOIs	https://doi.org/10.1007/s00108-023-01543-9
Publication status	Published - 08.2023

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)
Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

205-14 Haematology, Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00108-023-01543-9

Cite this

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title = "B-Symptomatik bei unklarer mediastinaler Lymphadenopathie: Fallbericht eines 72-j{\"a}hrigen Patienten mit VEXAS-Syndrom",

abstract = "The case of a 72-year-old male patient who presented to our centre for rare diseases with recurrent fever, night sweats and weight loss with initially confirmed mediastinal lymphadenopathy is reported. Investigation of lymph node material was unrevealing. As an additional finding, the patient had a myelodysplastic syndrome. VEXAS syndrome (vacuoles, E1 enzyme, X‑linked, autoinflammatory, somatic) could be confirmed on the basis of a bone marrow biopsy and genetic testing.",

author = "A. Ripke and A. M{\"u}nchau and {von Bubnoff}, N. and S. Jendrek and S. Kopelke and C. K{\"u}mpers and P. Parschke and S. Schinke and C. Khandanpour",

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doi = "10.1007/s00108-023-01543-9",

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T1 - B-Symptomatik bei unklarer mediastinaler Lymphadenopathie

T2 - Fallbericht eines 72-jährigen Patienten mit VEXAS-Syndrom

AU - Ripke, A.

AU - Münchau, A.

AU - von Bubnoff, N.

AU - Jendrek, S.

AU - Kopelke, S.

AU - Kümpers, C.

AU - Parschke, P.

AU - Schinke, S.

AU - Khandanpour, C.

PY - 2023/8

Y1 - 2023/8

N2 - The case of a 72-year-old male patient who presented to our centre for rare diseases with recurrent fever, night sweats and weight loss with initially confirmed mediastinal lymphadenopathy is reported. Investigation of lymph node material was unrevealing. As an additional finding, the patient had a myelodysplastic syndrome. VEXAS syndrome (vacuoles, E1 enzyme, X‑linked, autoinflammatory, somatic) could be confirmed on the basis of a bone marrow biopsy and genetic testing.

AB - The case of a 72-year-old male patient who presented to our centre for rare diseases with recurrent fever, night sweats and weight loss with initially confirmed mediastinal lymphadenopathy is reported. Investigation of lymph node material was unrevealing. As an additional finding, the patient had a myelodysplastic syndrome. VEXAS syndrome (vacuoles, E1 enzyme, X‑linked, autoinflammatory, somatic) could be confirmed on the basis of a bone marrow biopsy and genetic testing.

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U2 - 10.1007/s00108-023-01543-9

DO - 10.1007/s00108-023-01543-9

M3 - Übersichtsarbeiten

AN - SCOPUS:85168339656

SN - 2731-7080

VL - 64

SP - 810

EP - 814

JO - Innere Medizin (Germany)

JF - Innere Medizin (Germany)

IS - 8

ER -

B-Symptomatik bei unklarer mediastinaler Lymphadenopathie: Fallbericht eines 72-jährigen Patienten mit VEXAS-Syndrom

Abstract

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

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