Autoreactive T cell responses in pemphigus and pemphigoid

Gertie J. Oostingh, Cassian Sitaru, Arno Kromminga, Dirk Dormann, Detlef Zillikens*

*Corresponding author for this work
13 Citations (Scopus)


Pemphigus and pemphigoid are cutaneous autoimmune diseases characterised by autoantibodies directed against specific adhesion proteins of the epidermis and dermal-epidermal junction. These proteins are usually associated with desmosomes or hemidesmosomes. Binding of antibodies to their targets leads to the loss of cell-cell or cell-matrix adhesion and subsequently to blister formation. The humoral aspects of the autoimmune responses in pemphigus and pemphigoid have been extensively studied in the past. More recently, the cellular interactions resulting in the formation of autoantibodies and the involvement of autoreactive T cells in these diseases have attracted increased interest. In this review, the current knowledge on T cell involvement in pemphigus and pemphigoid is summarised.

Original languageEnglish
JournalAutoimmunity Reviews
Issue number5
Pages (from-to)267-272
Number of pages6
Publication statusPublished - 10.2002


Dive into the research topics of 'Autoreactive T cell responses in pemphigus and pemphigoid'. Together they form a unique fingerprint.

Cite this