Automated image analysis of immunohistochemical stained brain slices of long term polyimid brain implants

P. Klimach; A. Richter; S. Danner; C. Kruse; V. Tronnier; U. G. Hofmann

doi:10.1515/bmt-2012-4179

Automated image analysis of immunohistochemical stained brain slices of long term polyimid brain implants

P. Klimach, A. Richter, S. Danner, C. Kruse, V. Tronnier, U. G. Hofmann

Institute for Signal Processing

1 Citation (Scopus)

Abstract

The current quest for brain-machine-interfaces is hindered by the need to find a reliable solution for truly chronic brain implants. One approach to tackle that problem is not only to use flexible, mechanically compliant micro recording probes, but to enhance their acceptance in the target tissue by biologization. In order to shed light on the best modifications, immunohistochemical staining of long term implants in rat brains provided thousands of images over a six month experimental phase. The current work explains the image processing method, how these images were analysed in the least ambiguous way to provide meaningful and statistically relevant results. Quantitative analysis of the images allowed for the comparison of changes within the image and comparison between different images.

Original language	English
Journal	Biomedizinische Technik
Volume	57
Issue number	SUPPL. 1 TRACK-B
Pages (from-to)	481-484
Number of pages	4
ISSN	0013-5585
DOIs	https://doi.org/10.1515/bmt-2012-4179
Publication status	Published - 24.08.2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure
SDG 10 Reduced Inequalities
SDG 12 Responsible Consumption and Production
SDG 15 Life on Land

Access to Document

10.1515/bmt-2012-4179

Cite this

@article{d95d543d50ad4406babc755125d85edc,

title = "Automated image analysis of immunohistochemical stained brain slices of long term polyimid brain implants",

abstract = "The current quest for brain-machine-interfaces is hindered by the need to find a reliable solution for truly chronic brain implants. One approach to tackle that problem is not only to use flexible, mechanically compliant micro recording probes, but to enhance their acceptance in the target tissue by biologization. In order to shed light on the best modifications, immunohistochemical staining of long term implants in rat brains provided thousands of images over a six month experimental phase. The current work explains the image processing method, how these images were analysed in the least ambiguous way to provide meaningful and statistically relevant results. Quantitative analysis of the images allowed for the comparison of changes within the image and comparison between different images.",

author = "P. Klimach and A. Richter and S. Danner and C. Kruse and V. Tronnier and Hofmann, \{U. G.\}",

year = "2012",

month = aug,

day = "24",

doi = "10.1515/bmt-2012-4179",

language = "English",

volume = "57",

pages = "481--484",

journal = "Biomedizinische Technik",

issn = "0013-5585",

publisher = "Walter de Gruyter GmbH",

number = "SUPPL. 1 TRACK-B",

}

TY - JOUR

T1 - Automated image analysis of immunohistochemical stained brain slices of long term polyimid brain implants

AU - Klimach, P.

AU - Richter, A.

AU - Danner, S.

AU - Kruse, C.

AU - Tronnier, V.

AU - Hofmann, U. G.

PY - 2012/8/24

Y1 - 2012/8/24

N2 - The current quest for brain-machine-interfaces is hindered by the need to find a reliable solution for truly chronic brain implants. One approach to tackle that problem is not only to use flexible, mechanically compliant micro recording probes, but to enhance their acceptance in the target tissue by biologization. In order to shed light on the best modifications, immunohistochemical staining of long term implants in rat brains provided thousands of images over a six month experimental phase. The current work explains the image processing method, how these images were analysed in the least ambiguous way to provide meaningful and statistically relevant results. Quantitative analysis of the images allowed for the comparison of changes within the image and comparison between different images.

AB - The current quest for brain-machine-interfaces is hindered by the need to find a reliable solution for truly chronic brain implants. One approach to tackle that problem is not only to use flexible, mechanically compliant micro recording probes, but to enhance their acceptance in the target tissue by biologization. In order to shed light on the best modifications, immunohistochemical staining of long term implants in rat brains provided thousands of images over a six month experimental phase. The current work explains the image processing method, how these images were analysed in the least ambiguous way to provide meaningful and statistically relevant results. Quantitative analysis of the images allowed for the comparison of changes within the image and comparison between different images.

UR - https://www.scopus.com/pages/publications/84880616847

U2 - 10.1515/bmt-2012-4179

DO - 10.1515/bmt-2012-4179

M3 - Journal articles

AN - SCOPUS:84880616847

SN - 0013-5585

VL - 57

SP - 481

EP - 484

JO - Biomedizinische Technik

JF - Biomedizinische Technik

IS - SUPPL. 1 TRACK-B

ER -

Automated image analysis of immunohistochemical stained brain slices of long term polyimid brain implants

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this