The lung is frequently involved in disorders such as connective tissue diseases and small vessel vasculitides. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are often associated with alveolar haemorrhage and pulmonary granulomatous disease, whereas connective tissue disorders present with interstitial lung disease and pulmonary hypertension. Detection of ANCA directed against proteinase 3 or myeloperoxidase is helpful in the diagnosis of ANCA-associated vasculitis, and antinuclear antibodies (ANA) should be determined in cases of suspected connective tissue disease. Autoantibodies determined by ANA differentiation are often very specific for a certain type of connective tissue disease, e.g. antitopoisomerase-1 antibodies for systemic sclerosis. Autoantibody titres may correlate with disease activity or be associated with a special pattern of organ involvement and should be included in the diagnostics of connective tissue diseases and vasculitides.
|Translated title of the contribution||Autoantibody testing in vasculitides and connective tissue diseases with pulmonary manifestations|
|Number of pages||11|
|Publication status||Published - 2009|
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)