AUSGEDEHNTE REVERSIBLE GLOBALE LINKSVENTRIKULARE KONTRAKTIONSSTORUNG ALS FOLGE EINER ZYTOSTATISCHEN THERAPIE MIT 5-FLUOROURACIL BEI UNAUFFALLIGEM KORONARSYSTEM

M. Unverdorben; S. Birkenhake; B. Kunkel; J. Dunst

AUSGEDEHNTE REVERSIBLE GLOBALE LINKSVENTRIKULARE KONTRAKTIONSSTORUNG ALS FOLGE EINER ZYTOSTATISCHEN THERAPIE MIT 5-FLUOROURACIL BEI UNAUFFALLIGEM KORONARSYSTEM

Translated title of the contribution: Reversible global left ventricular dysfunction in patent coronar arteries following continuous infusion of 5-fluorouracil (5-FU)

M. Unverdorben, S. Birkenhake^*, B. Kunkel, J. Dunst

^*Corresponding author for this work

Clinic of Radiotherapy

University of Erlangen–Nuremberg

5 Citations (Scopus)

Abstract

Case Report: We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a 'hibernating myocardium' during continuous infusion of 5-FU. Conclusion: In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogeneic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.

Translated title of the contribution	Reversible global left ventricular dysfunction in patent coronar arteries following continuous infusion of 5-fluorouracil (5-FU)
Original language	German
Journal	Strahlentherapie und Onkologie
Volume	170
Issue number	8
Pages (from-to)	461-466
Number of pages	6
ISSN	0179-7158
Publication status	Published - 1994

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title = "AUSGEDEHNTE REVERSIBLE GLOBALE LINKSVENTRIKULARE KONTRAKTIONSSTORUNG ALS FOLGE EINER ZYTOSTATISCHEN THERAPIE MIT 5-FLUOROURACIL BEI UNAUFFALLIGEM KORONARSYSTEM",

abstract = "Case Report: We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a 'hibernating myocardium' during continuous infusion of 5-FU. Conclusion: In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogeneic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.",

author = "M. Unverdorben and S. Birkenhake and B. Kunkel and J. Dunst",

year = "1994",

language = "Deutsch",

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AU - Unverdorben, M.

AU - Birkenhake, S.

AU - Kunkel, B.

AU - Dunst, J.

PY - 1994

Y1 - 1994

N2 - Case Report: We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a 'hibernating myocardium' during continuous infusion of 5-FU. Conclusion: In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogeneic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.

AB - Case Report: We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a 'hibernating myocardium' during continuous infusion of 5-FU. Conclusion: In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogeneic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.

UR - http://www.scopus.com/inward/record.url?scp=0028149063&partnerID=8YFLogxK

M3 - Zeitschriftenaufsätze

C2 - 8085212

AN - SCOPUS:0028149063

SN - 0179-7158

VL - 170

SP - 461

EP - 466

JO - Strahlentherapie und Onkologie

JF - Strahlentherapie und Onkologie

IS - 8

ER -

AUSGEDEHNTE REVERSIBLE GLOBALE LINKSVENTRIKULARE KONTRAKTIONSSTORUNG ALS FOLGE EINER ZYTOSTATISCHEN THERAPIE MIT 5-FLUOROURACIL BEI UNAUFFALLIGEM KORONARSYSTEM

Abstract

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