Case Report: We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a 'hibernating myocardium' during continuous infusion of 5-FU. Conclusion: In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogeneic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.
|Translated title of the contribution||Reversible global left ventricular dysfunction in patent coronar arteries following continuous infusion of 5-fluorouracil (5-FU)|
|Journal||Strahlentherapie und Onkologie|
|Number of pages||6|
|Publication status||Published - 1994|