Attitudes and Viewpoints Toward Prevention Trials in Alzheimer's Disease

Philipp Pauli*, Katja Goetz, Annette Rogge, Thorsten Bartsch, Sarah Philippen, Daniela Berg, Katrin Hertrampf

*Corresponding author for this work


Alzheimer's disease (AD) prevention studies use biomarkers to determine risk in asymptomatic study participants. This involves multifaceted implications. Determinants regarding participation in these trials are therefore of particular relevance. We used semistructured individual interviews to interview uninvolved persons (n = 10), relatives of Alzheimer's patients (n = 10), and patients with mild cognitive impairment (n = 5) and analyzed the interviews using qualitative content analysis according to Mayring. We discovered various factors to be positive motivations for participation; the most significant inhibiting factor was concern about negative psychological effects. These motivations and concerns should be specifically addressed in the study design of AD prevention trials. The fears and concerns expressed highlight the importance of a good methodological and ethical framework to increase participant acceptance.

Original languageEnglish
JournalGeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry
Publication statusPublished - 2023


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