Atopische Dermatitis: Borretschol zur systemischen Therapie

In a randomised placebo controlled double blind study, 50 adult patients with mild to moderate atopic dermatitis were treated with borage oil (verum) or palm oil (placebo) for 12 weeks. Besides the drug under investigation only nonspecific topical ointments and creams were allowed to use. The ADASI (Atopic Dermatitis Area Severity Index)-score was measured daily. The ADASI itself is defined by the severity of eczema and the intensity of pruritus and allows an estimation of the intraindividual efficacy of the drug. In addition, the essential fatty acids and the IgE in the sera were measured. 18 patients of the verum-group and 14 patients of the placebo-group finished the study. After 12 weeks of therapy with daily 2 x 1,000 mg borage oil (Glandol®) or daily 2 x 1,000 mg palm oil (placebo), inside the verum-group, in 14 of 18 (78%) of the patients, the ADASI-score increased significantly, inside the placebo-group, in 6 of 14 (43%) of the patients (p < 0.05). Parallel to the improvement of the atopic dermatitis in the verum-group, the dihomo-gammalinolenic acid in serum increased significantly (p < 0.05). There was also an increase for gammalinolenic acid and arachidonic acid. There was no significant change in the total amount of serum IgE before and after therapy. In the present study borage oil showed good effects on the course of mild to moderate atopic dermatitis.