Association of the CD226 Ser307 variant with systemic sclerosis

P. Dieudé*, M. Guedj, M. E. Truchetet, J. Wipff, L. Revillod, G. Riemekasten, M. Matucci-Cerinic, I. Melchers, E. Hachulla, P. Airo, E. Diot, N. Hunzelmann, L. Mouthon, J. Cabane, J. L. Cracowski, V. Riccieri, J. Distler, Z. Amoura, G. Valentini, P. CamaraschiI. Tarner, C. Frances, P. Carpentier, N. C. Brembilla, O. Meyer, A. Kahan, C. Chizzolini, C. Boileau, Y. Allanore

*Corresponding author for this work
49 Citations (Scopus)


Objective: The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity. The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations. Methods: CD226 rs763361 was genotyped in 3,632 individuals, consisting of a discovery sample (991 SSc patients and 1,008 controls) and a replication sample (999 SSc patients and 634 controls). All study subjects.

Original languageEnglish
JournalArthritis and Rheumatism
Issue number4
Pages (from-to)1097-1105
Number of pages9
Publication statusPublished - 04.2011

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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