Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Sarah Doernberg; Bernhard Schaaf; Klaus Dalhoff; Lin Leng; Anna Beitin; Vincent Quagliarello; Richard Bucala

doi:10.1016/j.cyto.2010.12.010

Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Sarah Doernberg^*, Bernhard Schaaf, Klaus Dalhoff, Lin Leng, Anna Beitin, Vincent Quagliarello, Richard Bucala

^*Corresponding author for this work

Clinic of Internal Medicine III - Pulmonology

Yale University

15 Citations (Scopus)

Abstract

Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

Original language	English
Journal	Cytokine
Volume	53
Issue number	3
Pages (from-to)	292-294
Number of pages	3
ISSN	1043-4666
DOIs	https://doi.org/10.1016/j.cyto.2010.12.010
Publication status	Published - 01.03.2011

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10.1016/j.cyto.2010.12.010

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title = "Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae",

abstract = "Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.",

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AU - Beitin, Anna

AU - Quagliarello, Vincent

AU - Bucala, Richard

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AB - Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

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Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Abstract

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