TY - JOUR
T1 - Association of initial response to prednisone treatment in childhood acute lymphoblastic leukemia and polymorphisms within the tumour necrosis factor and the interleukin-10 genes
AU - Lauten, M.
AU - Matthias, T.
AU - Stanulla, M.
AU - Beger, C.
AU - Welte, K.
AU - Schrappe, M.
N1 - Funding Information:
We would like to thank all the participants of the ALL-BFM 86 and 90 studies as well as all doctors and nurses of participating medical centres for their excellent cooperation. This study was partly supported by: Madeleine-Schickedanz-Kind-erkrebsstiftung, Fürth, Germany and Erich und Emmy Hosel-mann-Stiftung, Hannover, Germany.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Plasma levels of TNF and IL-10 have been associated with therapy outcome in haematological malignancies and are influenced by genetic variation due to germline polymorphisms within the TNF and IL-10 genes. Different TNF and IL-10 genetic polymorphisms might therefore also correlate with clinical outcome in childhood acute lymphoblastic leukaemia (ALL). We analysed the association of TNF and IL-10 polymorphisms with response to initial treatment and risk of relapse in 135 children with ALL, treated according to Berlin-Frankfurt-Münster (BFM) protocols. Our data showed a protective effect from prednisone poor response in patients with the IL-10 G/G genotype, whereas no association of the risk of relapse and IL-10 genotype was found. In the total study group, subjects expressing the TNF2 allele neither showed a statistically significant general association with prednisone response nor with risk of relapse compared to subjects homozygous for the TNF1 allele. Nevertheless, we did find a higher risk of relapse in poor prednisone responders expressing the TNF2 allele compared to poor prednisone responders not expressing the TNF2 allele. We conclude that IL-10 genotype might influence prednisone response in patients with childhood ALL, whereas TNF genotype seems to influence the risk of relapse in high risk ALL patients.
AB - Plasma levels of TNF and IL-10 have been associated with therapy outcome in haematological malignancies and are influenced by genetic variation due to germline polymorphisms within the TNF and IL-10 genes. Different TNF and IL-10 genetic polymorphisms might therefore also correlate with clinical outcome in childhood acute lymphoblastic leukaemia (ALL). We analysed the association of TNF and IL-10 polymorphisms with response to initial treatment and risk of relapse in 135 children with ALL, treated according to Berlin-Frankfurt-Münster (BFM) protocols. Our data showed a protective effect from prednisone poor response in patients with the IL-10 G/G genotype, whereas no association of the risk of relapse and IL-10 genotype was found. In the total study group, subjects expressing the TNF2 allele neither showed a statistically significant general association with prednisone response nor with risk of relapse compared to subjects homozygous for the TNF1 allele. Nevertheless, we did find a higher risk of relapse in poor prednisone responders expressing the TNF2 allele compared to poor prednisone responders not expressing the TNF2 allele. We conclude that IL-10 genotype might influence prednisone response in patients with childhood ALL, whereas TNF genotype seems to influence the risk of relapse in high risk ALL patients.
UR - http://www.scopus.com/inward/record.url?scp=0036048236&partnerID=8YFLogxK
U2 - 10.1038/sj.leu.2402545
DO - 10.1038/sj.leu.2402545
M3 - Journal articles
C2 - 12145682
AN - SCOPUS:0036048236
SN - 0887-6924
VL - 16
SP - 1437
EP - 1442
JO - Leukemia
JF - Leukemia
IS - 8
ER -
