Assignment of the orphan nuclear receptor Nurr1 by NMR

Paul Michiels, Karen Atkins, Christian Ludwig, Sara Whittaker, Maria Van Dongen, Ulrich Günther*

*Corresponding author for this work
7 Citations (Scopus)


The orphan nuclear receptor Nurr1 has been implicated in a number of conditions including Parkinson's disease and Schizophrenia. As such, it is of interest to study its interactions with other proteins, possibly mediated by small molecules, considering possible use as a drug target. We produced 2H, 15N, 13C labelled-Nurr1 to generate the backbone amide NH, carbonyl C′, Calpha and Cbeta assignments. About 84.0% of residues could be assigned. Most of the 37 missing assignments fall in 3 regions of the protein. Two of these surround a putative ligand-binding region of Nurr1, suggesting that this region of the protein is flexible, despite the ligand-binding pocket being filled with hydrophobic side-chains from residues surrounding the ligand binding pocket.

Original languageEnglish
JournalBiomolecular NMR Assignments
Issue number1
Pages (from-to)101-105
Number of pages5
Publication statusPublished - 04.2010

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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