TY - JOUR
T1 - Assessment of luteinizing hormone level in the gonadotropin-releasing hormone antagonist protocol
AU - Griesinger, Georg
AU - Dawson, Anja
AU - Schultze-Mosgau, Askan
AU - Finas, Dominique
AU - Diedrich, Klaus
AU - Felberbaum, Ricardo
PY - 2006/3
Y1 - 2006/3
N2 - In the GnRH-antagonist multiple-dose protocol, the LH level retrieved from a single measurement during ovarian stimulation and concomitant GnRH-antagonist administration can vary according to [1] the time point of sampling with respect to the GnRH-antagonist injection and [2] episodic changes in circulating LH concentration due to the pulsatile release of LH from the pituitary gland. To exemplify the size of pharmacodynamic effect of a single 0.25-mg cetrorelix administration on LH concentration profile and pulsatility, we measured endogenous LH levels every 15 minutes from 8 hours before the first cetrorelix administration until 24 hours thereafter on ovarian stimulation day 6 and 7 in a single patient.
AB - In the GnRH-antagonist multiple-dose protocol, the LH level retrieved from a single measurement during ovarian stimulation and concomitant GnRH-antagonist administration can vary according to [1] the time point of sampling with respect to the GnRH-antagonist injection and [2] episodic changes in circulating LH concentration due to the pulsatile release of LH from the pituitary gland. To exemplify the size of pharmacodynamic effect of a single 0.25-mg cetrorelix administration on LH concentration profile and pulsatility, we measured endogenous LH levels every 15 minutes from 8 hours before the first cetrorelix administration until 24 hours thereafter on ovarian stimulation day 6 and 7 in a single patient.
UR - http://www.scopus.com/inward/record.url?scp=32944482510&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2005.08.048
DO - 10.1016/j.fertnstert.2005.08.048
M3 - Journal articles
C2 - 16500366
AN - SCOPUS:32944482510
SN - 0015-0282
VL - 85
SP - 791
EP - 793
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 3
ER -
