Assessment of left ventricular function with single breath-hold highly accelerated cine MRI combined with guide-point modeling

Christina Heilmaier, Kai Nassenstein, Sonia Nielles-Vallespin, Sven Zuehlsdorff, Peter Hunold, Joerg Barkhausen*

*Corresponding author for this work
6 Citations (Scopus)

Abstract

Purpose: To prospectively assess the performance of highly accelerated cine MRI in multi-orientations combined with a new guide-point modeling post-processing technique (GPM approach) for assessment of left ventricular (LV) function compared to the standard summation of slices method based on a stack of short axis views (SoS approach). Materials and methods: 33 consecutive patients were examined on a 1.5 T scanner with a standard steady state free precession (SSFP) sequence (TR, 3.0 ms; TE, 1.5 m; flip angle (FA), 60°; acceleration factor (AF), 2) analyzed with the SoS method and a highly accelerated, single breath-hold temporal parallel acquisition SSFP sequence (TR, 4.6 ms; TE, 1.1 ms; AF, 3) post-processed with the GPM method. LV function values were measured by two independent readers with different experience in cardiac MRI and compared by using the paired t-test and F-test. Inter- and intraobserver agreements were calculated using Bland-Altman-Plots. Results: Mean acquisition and post-processing time was significantly shorter with the GPM approach (15 s/3 min versus 360 s/6 min). For all LV function parameters interobserver agreement between the experienced and non-experienced reader was significantly improved when the GPM approach was used. However, end-diastolic and end-systolic volumes were larger for the GPM technique when compared to the SoS method (P < 0.001), whereas ejection fraction estimation yielded equivalent results (P > 0.121). In both readers and for all parameters variances did not differ significantly (P ≥ 0.409) and the two approaches showed an excellent linear correlation (r > 0.951). Conclusion: Due to its accurate, fast and reproducible assessment of LV function parameters highly accelerated MRI combined with the GPM technique may become the technique of first choice for assessment of LV function in clinical routine.

Original languageEnglish
JournalEuropean Journal of Radiology
Volume74
Issue number3
Pages (from-to)492-499
Number of pages8
ISSN0720-048X
DOIs
Publication statusPublished - 01.06.2010

Research Areas and Centers

  • Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

  • 205-32 Medical Physics, Biomedical Engineering
  • 205-30 Radiology, Nuclear Medicine, Radiation Therapy and Radiobiology

Fingerprint

Dive into the research topics of 'Assessment of left ventricular function with single breath-hold highly accelerated cine MRI combined with guide-point modeling'. Together they form a unique fingerprint.

Cite this