Assessment of Laser Parameters to Improve Lid Tension—A Proof of Concept towards Lasercanthoplasty

Christoph Holtmann, Witt Joana, Schilcher Alexandra, Amar Advakovic, Alessa Hutfilz, Dirk Theisen-Kunde, Katharina Wiebe-Ben Zakour, Knop Erich, Gerling Gerd

Abstract

Background: Preliminary clinical work indicates that increasing eyelid tension improves the function of the meibomian glands. The aim of this study was to optimize laser parameters for a minimally invasive laser treatment to increase eyelid tension by coagulation of the lateral tarsal plate and canthus. Methods: Experiments were performed on a total of 24 porcine lower lids post mortem, with six lids in each group. Three groups were irradiated with an infrared B radiation laser. Laser-induced lower eyelid shortening was measured and the increase in eyelid tension was assessed with a force sensor. A histology was performed to evaluate coagulation size and laser-induced tissue damage. Results: In all three groups, a significant shortening of the eyelids after irradiation was noticed (p < 0.0001). The strongest effect was seen with 1940 nm/1 W/5 s, showing −15.1 ± 3.7% and −2.5 ± 0.6 mm lid shortening. The largest significant increase in eyelid tension was seen after placing the third coagulation. Conclusion: Laser coagulation leads to lower eyelid shortening and an increase in lower eyelid tension. The strongest effect with the least tissue damage was shown for laser parameters of 1470 nm/2.5 W/2 s. In vivo studies of this effect have to confirm the efficacy of this concept prior to clinical application.
Original languageEnglish
Article number4757
JournalInternational Journal of Molecular Sciences
Volume24
Issue number5
Pages (from-to)4757
ISSN1422-0067
DOIs
Publication statusPublished - 01.03.2023

DFG Research Classification Scheme

  • 308-01 Optics, Quantum Optics, Atoms, Molecules, Plasmas

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