TY - JOUR
T1 - Assessment of 'dry skin': Current bioengineering methods and test designs
AU - Fischer, Tobias W.
AU - Wigger-Alberti, Walter
AU - Elsner, Peter
PY - 2001
Y1 - 2001
N2 - Dry skin is a frequent problem in dermatology and a sign of dysfunction of the epidermis, especially of the stratum corneum as the morphological equivalent of the skin barrier. It may occur as an individual disposition or as the leading symptom of atopic dermatitis or ichthyosis. Besides the visual examination of the skin, various bioengineering methods have been developed to assess the different pathological and adaptive changes in the skin. In addition to the assessment of skin humidity, barrier function and desquamation, the quantification of skin surface topography and the mechanical properties of skin are suitable methods to characterize a dry skin condition. For clinical assessment of moisturizing products and emollients the parameters of investigation have to be defined and integrated in an adapted study design depending on the composition and content of the active agent in the test product. Newly developed cosmetic products have to be investigated for safety and efficacy. Modern bioengineering methods are suitable to fulfill these challenges.
AB - Dry skin is a frequent problem in dermatology and a sign of dysfunction of the epidermis, especially of the stratum corneum as the morphological equivalent of the skin barrier. It may occur as an individual disposition or as the leading symptom of atopic dermatitis or ichthyosis. Besides the visual examination of the skin, various bioengineering methods have been developed to assess the different pathological and adaptive changes in the skin. In addition to the assessment of skin humidity, barrier function and desquamation, the quantification of skin surface topography and the mechanical properties of skin are suitable methods to characterize a dry skin condition. For clinical assessment of moisturizing products and emollients the parameters of investigation have to be defined and integrated in an adapted study design depending on the composition and content of the active agent in the test product. Newly developed cosmetic products have to be investigated for safety and efficacy. Modern bioengineering methods are suitable to fulfill these challenges.
UR - http://www.scopus.com/inward/record.url?scp=0034916663&partnerID=8YFLogxK
U2 - 10.1159/000056346
DO - 10.1159/000056346
M3 - Scientific review articles
C2 - 11464100
AN - SCOPUS:0034916663
SN - 1422-2868
VL - 14
SP - 183
EP - 195
JO - Skin Pharmacology and Applied Skin Physiology
JF - Skin Pharmacology and Applied Skin Physiology
IS - 4
ER -