TY - JOUR
T1 - Assessment of disease activity in large-vessel vasculitis: Results of an international delphi exercise
AU - International Delphi on Disease Activity Assessment in Large-vessel Vasculitis
AU - Aydin, Sibel Z.
AU - Direskeneli, Haner
AU - Merkel, Peter A.
AU - Toloza, Sergio
AU - Blockmans, Daniel
AU - Sato, Emilia Inoue
AU - De Souza, Alexandre Wagner Silva
AU - Cabral, David
AU - Carette, Simon
AU - Famorca, Leilani
AU - Khalidi, Nader
AU - Milman, Nataliya
AU - Yacyshyn, Elaine
AU - Tesar, Vladimir
AU - Baslund, Bo
AU - Faurschou, Mikkel
AU - Guillevin, Loïc
AU - Puéchal, Xavier
AU - Aries, Peer
AU - Hellmich, Bernhard
AU - Herlyn, Karen
AU - Holle, Julia
AU - Lamprecht, Peter
AU - Moosig, Frank
AU - Neumann, Thomas
AU - Zwerina, Jochen
AU - Tómasson, Gunnar
AU - Bambery, Pradeep
AU - Jois, Ramesh
AU - Rajasekhar, Liza
AU - Sharma, Aman
AU - Sivakumar, Rajappa
AU - Molloy, Eamonn
AU - Hashkes, Philip
AU - Catapano, Fausta
AU - Cimino, Luca
AU - De Fanti, Alessandro
AU - Pipitone, Nicolo
AU - Salvarani, Carlo
AU - Vaglio, Augusto
AU - Kobayashi, Shigeto
AU - Suzuki, Kazuo
AU - Flores-Suárez, Luis Felipe
AU - Hinojosa-Azaola, Andrea
AU - Brouwer, Elisabeth
AU - Rutgers, Abraham
AU - Stegeman, Coen
AU - Suppiah, Ravi
AU - Hollan, Ivana
AU - Arguis, Pedro
N1 - Funding Information:
Sponsored by the Vasculitis Clinical Research Consortium, which has received support from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319 and U01 AR51874 04), the National Center for Research Resources (U54 RR019497), and the Office of Rare Diseases Research. Additional support for the work of the OMERACT Vasculitis Working Group was received through a Patient-Centered Outcomes Research Institute Pilot Project Grant. S.Z. Aydin, MD, Associate Professor, Division of Rheumatology, The Ottawa Hospital Research Institute, University of Ottawa; H. Direskeneli, MD, Professor of Rheumatology, Division of Rheumatology, Marmara University Faculty of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology, and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Section of Rheumatology, University of Pennsylvania, White Building, 5th Floor Penn, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: [email protected] Accepted for publication June 3, 2017.
Publisher Copyright:
Copyright © 2017. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.
AB - Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85037094161&partnerID=8YFLogxK
U2 - 10.3899/jrheum.161269
DO - 10.3899/jrheum.161269
M3 - Journal articles
C2 - 28864648
AN - SCOPUS:85037094161
SN - 0315-162X
VL - 44
SP - 1928
EP - 1932
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 12
ER -
