Aspergillus in the intensive care unit

Markus Ruhnke*, Peter Kujath, Dirk Vogelaers

*Corresponding author for this work


Invasive aspergillosis (IA), the most life-threatening form of aspergillosis, has become a major opportunistic fungal disease in immunocompromised patients. In high-risk patients with hematologic malignancies, IA appears to decline with the use of mold-active antifungal prophylaxis, but the situation is less clear in other patient groups at risk for IA, and precise epidemiologic data from patients treated in intensive care units (ICUs) are lacking. Most Aspergillus culture isolates from nonsterile body sites do not represent disease, but isolation of Aspergillus in critically ill patients is a marker of poor prognosis and is associated with high mortality regardless of invasion or colonization. This review presents current information on epidemiology, risk factors, and diagnosis, and discusses treatment options for patients with IA in the ICU.

Original languageEnglish
JournalCurrent Fungal Infection Reports
Issue number1
Pages (from-to)63-73
Number of pages11
Publication statusPublished - 01.03.2012


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