Approaches to Understanding COVID-19 and its Neurological Associations

on behalf of the Global COVID-19 Neuro Research Coalition; Ettore Beghi; Benedict D. Michael; Tom Solomon; Erica Westenberg; Andrea S. Winkler; Ettore Beghi; Benedict D. Michael; Tom Solomon; Erica Westenberg; Andrea S. Winkler; Samuel Knauss; Jim Sejvar; Omar Siddiqi; M. Netravathi; Augustina Charway-Felli; Foad Abd-Allah; Claudio Bassetti; Maria Lúcia Brito Ferreira; Sherry Hsiang Yi Chou; Josep Dalmau; Guillermo Delgado-García; Ava Easton; Julius Emmrich; Matthias Endres; Agnès Fleury; Jennifer A. Frontera; David García-Azorín; Alla Guekht; Raimund Helbok; Kerstin Hellwig; Günter Höglinger; Fan Kee Hoo; Christine Klein; Suzannah Lant; Molly McNett; Elena Moro; Alessandro Padovani; Bettina Pfausler; Kameshwar Prasad; Gustavo C. Roman; Fred S. Sarfo; Parthasarathy Satishchandra; Deanna Saylor; Marianna Spatola; Peter Spencer; Richard J. Stark; Matthis Synofzik; Pille Taba; Fabrizio Tagliavini; Kiran T. Thakur

doi:10.1002/ana.26076

Approaches to Understanding COVID-19 and its Neurological Associations

on behalf of the Global COVID-19 Neuro Research Coalition, Ettore Beghi, Benedict D. Michael, Tom Solomon, Erica Westenberg, Andrea S. Winkler, Ettore Beghi, Benedict D. Michael, Tom Solomon, Erica Westenberg, Andrea S. Winkler, Samuel Knauss, Jim Sejvar, Omar Siddiqi, M. Netravathi, Augustina Charway-Felli, Foad Abd-Allah, Claudio Bassetti, Maria Lúcia Brito Ferreira, Sherry Hsiang Yi ChouJosep Dalmau, Guillermo Delgado-García, Ava Easton, Julius Emmrich, Matthias Endres, Agnès Fleury, Jennifer A. Frontera, David García-Azorín, Alla Guekht, Raimund Helbok, Kerstin Hellwig, Günter Höglinger, Fan Kee Hoo, Christine Klein, Suzannah Lant, Molly McNett, Elena Moro, Alessandro Padovani, Bettina Pfausler, Kameshwar Prasad, Gustavo C. Roman, Fred S. Sarfo, Parthasarathy Satishchandra, Deanna Saylor, Marianna Spatola, Peter Spencer, Richard J. Stark, Matthis Synofzik, Pille Taba, Fabrizio Tagliavini, Kiran T. Thakur

Institute of Neurogenetics

21 Citations (Scopus)

Abstract

There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID-19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID-19 neurological complications and harmonized clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low-income settings. ANN NEUROL 2021;89:1059–1067.

Original language	English
Journal	Annals of Neurology
Volume	89
Issue number	6
Pages (from-to)	1059-1067
Number of pages	9
ISSN	0364-5134
DOIs	https://doi.org/10.1002/ana.26076
Publication status	Published - 06.2021

Funding

We would like to acknowledge the following organizations for their commitment to monitoring and understanding the neurological manifestations of COVID‐19: the European Academy of Neurology (EAN), the German Society of Neurology (DGN), the Global Consortium Study of Neurological Dysfunction in COVID‐19 (GCS‐NeuroCOVID), the CoroNerve Study Group, the Brain Infections Global COVID‐Neuro Network, the WHO Brain Health Unit with its Neuro‐COVID Global Forum, and the World Federation of Neurology (WFN). We also acknowledge the national registries of Italy, Spain, Germany, USA, and Mexico, with gratitude to their coordinators for providing us with their data collection structures. We also give special thanks to Professor Bernhard Hemmer, Department of Neurology, Technical University of Munich, for his ongoing support of the COVID‐19 Neuro Research Coalition, and to Erica Westenberg and Annette Abraham for coordinating the Coalition. ASW reports funding by the School of Medicine, Technical University of Munich, Grant Number H.40001.1.7‐08 in support of the global COVID‐19 Neuro Research Coalition. We would like to acknowledge the following organizations for their commitment to monitoring and understanding the neurological manifestations of COVID-19: the European Academy of Neurology (EAN), the German Society of Neurology (DGN), the Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID), the CoroNerve Study Group, the Brain Infections Global COVID-Neuro Network, the WHO Brain Health Unit with its Neuro-COVID Global Forum, and the World Federation of Neurology (WFN). We also acknowledge the national registries of Italy, Spain, Germany, USA, and Mexico, with gratitude to their coordinators for providing us with their data collection structures. We also give special thanks to Professor Bernhard Hemmer, Department of Neurology, Technical University of Munich, for his ongoing support of the COVID-19 Neuro Research Coalition, and to Erica Westenberg and Annette Abraham for coordinating the Coalition. ASW reports funding by the School of Medicine, Technical University of Munich, Grant Number H.40001.1.7-08 in support of the global COVID-19 Neuro Research Coalition.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Medical Genetics

Coronavirus related work

Research on SARS-CoV-2 / COVID-19

Access to Document

10.1002/ana.26076

Cite this

on behalf of the Global COVID-19 Neuro Research Coalition, Beghi, E., Michael, B. D., Solomon, T., Westenberg, E., Winkler, A. S., Beghi, E., Michael, B. D., Solomon, T., Westenberg, E., Winkler, A. S., Knauss, S., Sejvar, J., Siddiqi, O., Netravathi, M., Charway-Felli, A., Abd-Allah, F., Bassetti, C., Ferreira, M. L. B., ... Thakur, K. T. (2021). Approaches to Understanding COVID-19 and its Neurological Associations. Annals of Neurology, 89(6), 1059-1067. https://doi.org/10.1002/ana.26076

@article{307020636a0b4a5a88f93448a5d4dd3a,

title = "Approaches to Understanding COVID-19 and its Neurological Associations",

abstract = "There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID-19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID-19 neurological complications and harmonized clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low-income settings. ANN NEUROL 2021;89:1059–1067.",

author = "\{on behalf of the Global COVID-19 Neuro Research Coalition\} and Ettore Beghi and Michael, \{Benedict D.\} and Tom Solomon and Erica Westenberg and Winkler, \{Andrea S.\} and Ettore Beghi and Michael, \{Benedict D.\} and Tom Solomon and Erica Westenberg and Winkler, \{Andrea S.\} and Samuel Knauss and Jim Sejvar and Omar Siddiqi and M. Netravathi and Augustina Charway-Felli and Foad Abd-Allah and Claudio Bassetti and Ferreira, \{Maria L{\'u}cia Brito\} and Chou, \{Sherry Hsiang Yi\} and Josep Dalmau and Guillermo Delgado-Garc{\'i}a and Ava Easton and Julius Emmrich and Matthias Endres and Agn{\`e}s Fleury and Frontera, \{Jennifer A.\} and David Garc{\'i}a-Azor{\'i}n and Alla Guekht and Raimund Helbok and Kerstin Hellwig and G{\"u}nter H{\"o}glinger and Hoo, \{Fan Kee\} and Christine Klein and Suzannah Lant and Molly McNett and Elena Moro and Alessandro Padovani and Bettina Pfausler and Kameshwar Prasad and Roman, \{Gustavo C.\} and Sarfo, \{Fred S.\} and Parthasarathy Satishchandra and Deanna Saylor and Marianna Spatola and Peter Spencer and Stark, \{Richard J.\} and Matthis Synofzik and Pille Taba and Fabrizio Tagliavini and Thakur, \{Kiran T.\}",

note = "Publisher Copyright: {\textcopyright} 2021 American Neurological Association.",

year = "2021",

month = jun,

doi = "10.1002/ana.26076",

language = "English",

volume = "89",

pages = "1059--1067",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley \& Sons Inc.",

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}

on behalf of the Global COVID-19 Neuro Research Coalition, Beghi, E, Michael, BD, Solomon, T, Westenberg, E, Winkler, AS, Beghi, E, Michael, BD, Solomon, T, Westenberg, E, Winkler, AS, Knauss, S, Sejvar, J, Siddiqi, O, Netravathi, M, Charway-Felli, A, Abd-Allah, F, Bassetti, C, Ferreira, MLB, Chou, SHY, Dalmau, J, Delgado-García, G, Easton, A, Emmrich, J, Endres, M, Fleury, A, Frontera, JA, García-Azorín, D, Guekht, A, Helbok, R, Hellwig, K, Höglinger, G, Hoo, FK, Klein, C, Lant, S, McNett, M, Moro, E, Padovani, A, Pfausler, B, Prasad, K, Roman, GC, Sarfo, FS, Satishchandra, P, Saylor, D, Spatola, M, Spencer, P, Stark, RJ, Synofzik, M, Taba, P, Tagliavini, F & Thakur, KT 2021, 'Approaches to Understanding COVID-19 and its Neurological Associations', Annals of Neurology, vol. 89, no. 6, pp. 1059-1067. https://doi.org/10.1002/ana.26076

TY - JOUR

T1 - Approaches to Understanding COVID-19 and its Neurological Associations

AU - on behalf of the Global COVID-19 Neuro Research Coalition

AU - Beghi, Ettore

AU - Michael, Benedict D.

AU - Solomon, Tom

AU - Westenberg, Erica

AU - Winkler, Andrea S.

AU - Beghi, Ettore

AU - Michael, Benedict D.

AU - Solomon, Tom

AU - Westenberg, Erica

AU - Winkler, Andrea S.

AU - Knauss, Samuel

AU - Sejvar, Jim

AU - Siddiqi, Omar

AU - Netravathi, M.

AU - Charway-Felli, Augustina

AU - Abd-Allah, Foad

AU - Bassetti, Claudio

AU - Ferreira, Maria Lúcia Brito

AU - Chou, Sherry Hsiang Yi

AU - Dalmau, Josep

AU - Delgado-García, Guillermo

AU - Easton, Ava

AU - Emmrich, Julius

AU - Endres, Matthias

AU - Fleury, Agnès

AU - Frontera, Jennifer A.

AU - García-Azorín, David

AU - Guekht, Alla

AU - Helbok, Raimund

AU - Hellwig, Kerstin

AU - Höglinger, Günter

AU - Hoo, Fan Kee

AU - Klein, Christine

AU - Lant, Suzannah

AU - McNett, Molly

AU - Moro, Elena

AU - Padovani, Alessandro

AU - Pfausler, Bettina

AU - Prasad, Kameshwar

AU - Roman, Gustavo C.

AU - Sarfo, Fred S.

AU - Satishchandra, Parthasarathy

AU - Saylor, Deanna

AU - Spatola, Marianna

AU - Spencer, Peter

AU - Stark, Richard J.

AU - Synofzik, Matthis

AU - Taba, Pille

AU - Tagliavini, Fabrizio

AU - Thakur, Kiran T.

PY - 2021/6

Y1 - 2021/6

N2 - There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID-19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID-19 neurological complications and harmonized clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low-income settings. ANN NEUROL 2021;89:1059–1067.

AB - There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID-19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID-19 neurological complications and harmonized clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low-income settings. ANN NEUROL 2021;89:1059–1067.

UR - https://www.scopus.com/pages/publications/85105474665

UR - https://www.mendeley.com/catalogue/60e44d44-870c-3c88-893d-4692c126c988/

U2 - 10.1002/ana.26076

DO - 10.1002/ana.26076

M3 - Journal articles

C2 - 33836104

AN - SCOPUS:85105474665

SN - 0364-5134

VL - 89

SP - 1059

EP - 1067

JO - Annals of Neurology

JF - Annals of Neurology

IS - 6

ER -

Approaches to Understanding COVID-19 and its Neurological Associations

Abstract

Funding

UN SDGs

Research Areas and Centers

Coronavirus related work

Access to Document

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