Approaches to Understanding COVID-19 and its Neurological Associations

on behalf of the Global COVID-19 Neuro Research Coalition, Ettore Beghi, Benedict D. Michael, Tom Solomon, Erica Westenberg, Andrea S. Winkler, Ettore Beghi, Benedict D. Michael, Tom Solomon, Erica Westenberg, Andrea S. Winkler, Samuel Knauss, Jim Sejvar, Omar Siddiqi, M. Netravathi, Augustina Charway-Felli, Foad Abd-Allah, Claudio Bassetti, Maria Lúcia Brito Ferreira, Sherry Hsiang Yi ChouJosep Dalmau, Guillermo Delgado-García, Ava Easton, Julius Emmrich, Matthias Endres, Agnès Fleury, Jennifer A. Frontera, David García-Azorín, Alla Guekht, Raimund Helbok, Kerstin Hellwig, Günter Höglinger, Fan Kee Hoo, Christine Klein, Suzannah Lant, Molly McNett, Elena Moro, Alessandro Padovani, Bettina Pfausler, Kameshwar Prasad, Gustavo C. Roman, Fred S. Sarfo, Parthasarathy Satishchandra, Deanna Saylor, Marianna Spatola, Peter Spencer, Richard J. Stark, Matthis Synofzik, Pille Taba, Fabrizio Tagliavini, Kiran T. Thakur

1 Citation (Scopus)


There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID-19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID-19 neurological complications and harmonized clinical measures for future research. This will facilitate well-designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low-income settings. ANN NEUROL 2021;89:1059–1067.

Original languageEnglish
JournalAnnals of Neurology
Issue number6
Pages (from-to)1059-1067
Number of pages9
Publication statusPublished - 06.2021

Research Areas and Centers

  • Research Area: Medical Genetics

Coronavirus related work

  • Research on SARS-CoV-2 / COVID-19


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