TY - JOUR
T1 - Application of porcupine inhibitors in stem cell fate determination
AU - Kalantary-Charvadeh, Ashkan
AU - Hosseini, Vahid
AU - Mehdizadeh, Amir
AU - Darabi, Masoud
N1 - Funding Information:
The authors thank the Stem Cell Research Center (grant No.: 59523) and Faculty of Medicine at Tabriz University of Medical Sciences for the support throughout the study.
Funding Information:
The authors thank the Stem Cell Research Center (grant No.: 59523) and Faculty of Medicine at Tabriz University of Medical Sciences for the support throughout the study.
Publisher Copyright:
© 2020 John Wiley & Sons A/S
PY - 2020/10
Y1 - 2020/10
N2 - Porcupine (Porcn), a membrane-bound O-acyltransferase, is an endoplasmic reticulum-located protein that has catalytic activity. Porcn is involved in post-translational lipid modification of wingless-Int (Wnt) proteins and serves as an indispensable step in the Wnt proper secretion and signaling. Small-molecule inhibitors targeting Porcn catalytic function in vitro and in vivo are of great interest not only for treating cancer and fibrotic disorders but also in the field of regenerative medicine. Although a number of studies have been conducted, the exact role of Porcn in stem cell fate is not entirely clear. In some cases, Porcn inhibition declined differentiation rate, and in others, it induced stem cell differentiation toward specific lineages. In this review, we first elaborated the Porcn catalytic activity and its inhibitors. Then, we discussed about the recently reported results of Porcn inhibitors in stem cells self-renewal and differentiation.
AB - Porcupine (Porcn), a membrane-bound O-acyltransferase, is an endoplasmic reticulum-located protein that has catalytic activity. Porcn is involved in post-translational lipid modification of wingless-Int (Wnt) proteins and serves as an indispensable step in the Wnt proper secretion and signaling. Small-molecule inhibitors targeting Porcn catalytic function in vitro and in vivo are of great interest not only for treating cancer and fibrotic disorders but also in the field of regenerative medicine. Although a number of studies have been conducted, the exact role of Porcn in stem cell fate is not entirely clear. In some cases, Porcn inhibition declined differentiation rate, and in others, it induced stem cell differentiation toward specific lineages. In this review, we first elaborated the Porcn catalytic activity and its inhibitors. Then, we discussed about the recently reported results of Porcn inhibitors in stem cells self-renewal and differentiation.
UR - http://www.scopus.com/inward/record.url?scp=85087144911&partnerID=8YFLogxK
U2 - 10.1111/cbdd.13704
DO - 10.1111/cbdd.13704
M3 - Scientific review articles
C2 - 32419352
AN - SCOPUS:85087144911
SN - 1747-0277
VL - 96
SP - 1052
EP - 1068
JO - Chemical Biology and Drug Design
JF - Chemical Biology and Drug Design
IS - 4
ER -