TY - JOUR
T1 - Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68
AU - Sun, Liang
AU - Meijer, Adam
AU - Froeyen, Mathy
AU - Zhang, Linlin
AU - Thibaut, Hendrik Jan
AU - Baggen, Jim
AU - George, Shyla
AU - Vernachio, John
AU - Van Kuppeveld, Frank J.M.
AU - Leyssen, Pieter
AU - Hilgenfeld, Rolf
AU - Neyts, Johan
AU - Delang, Leen
PY - 2015/12/1
Y1 - 2015/12/1
N2 - We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A structural explanation of why both substitutions may cause resistance is provided.
AB - We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A structural explanation of why both substitutions may cause resistance is provided.
UR - http://www.scopus.com/inward/record.url?scp=84948126432&partnerID=8YFLogxK
U2 - 10.1128/AAC.01375-15
DO - 10.1128/AAC.01375-15
M3 - Journal articles
C2 - 26369972
AN - SCOPUS:84948126432
SN - 0066-4804
VL - 59
SP - 7782
EP - 7785
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 12
ER -
