TY - JOUR
T1 - "Antisurvival" factor treatment for hormone refractory prostate cancer: Secondary hormonal ablation using somatostatin analogs
AU - Schilling, David
AU - Küfer, Rainer
AU - Kruck, Stephan
AU - Waalkes, Sandra
AU - Stenzl, Arnulf
AU - Kuczyk, Markus A.
AU - Merseburger, Axel S.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011
Y1 - 2011
N2 - About 40 - 60% of the patients with prostate cancer in the hormone independent stage respond to a secondary hormonal manipulation with a temporary decrease of the serum prostate-specific antigen (PSA). PSA progression can be delayed for 4 - 8 months and the onset of a taxane-based chemotherapy with its potentially toxic side effects can be postponed. Traditionally second line antiandrogens, inhibitors of adrenal testosterone production, estrogens or progestin have been applied in secondary hormonal manipulation. Recently somatostatin analogs have been suggested for the treatment of hormone independent prostate cancer. By modulating intracellular pro-proliferative and anti-apoptotic signaling cascades somatostatin analogs influence the tumor cell micro-environment and inhibit tumor progression. In this review we focus on the mode of action and the clinical application of somatostatin analogs in the treatment of hormone- independent prostate cancer. The concept of an "anti-survival factor therapy" is discussed.
AB - About 40 - 60% of the patients with prostate cancer in the hormone independent stage respond to a secondary hormonal manipulation with a temporary decrease of the serum prostate-specific antigen (PSA). PSA progression can be delayed for 4 - 8 months and the onset of a taxane-based chemotherapy with its potentially toxic side effects can be postponed. Traditionally second line antiandrogens, inhibitors of adrenal testosterone production, estrogens or progestin have been applied in secondary hormonal manipulation. Recently somatostatin analogs have been suggested for the treatment of hormone independent prostate cancer. By modulating intracellular pro-proliferative and anti-apoptotic signaling cascades somatostatin analogs influence the tumor cell micro-environment and inhibit tumor progression. In this review we focus on the mode of action and the clinical application of somatostatin analogs in the treatment of hormone- independent prostate cancer. The concept of an "anti-survival factor therapy" is discussed.
UR - http://www.scopus.com/inward/record.url?scp=79551644191&partnerID=8YFLogxK
U2 - 10.2174/157339411794474173
DO - 10.2174/157339411794474173
M3 - Journal articles
AN - SCOPUS:79551644191
SN - 1573-3947
VL - 7
SP - 56
EP - 64
JO - Current Cancer Therapy Reviews
JF - Current Cancer Therapy Reviews
IS - 1
ER -