Antioxidant defense system in rats simultaneously intoxicated with agrochemicals

Mariana Astiz; María J.T. de Alaniz; Carlos Alberto Marra

doi:10.1016/j.etap.2009.07.009

Antioxidant defense system in rats simultaneously intoxicated with agrochemicals

Mariana Astiz, María J.T. de Alaniz, Carlos Alberto Marra^*

^*Corresponding author for this work

Institute of Neurobiology

Universidad Nacional de La Plata

78 Citations (Scopus)

Abstract

The effect of dimethoate, zineb and glyphosate administered alone or in combination on liver, kidney, brain and plasma antioxidant defense system was investigated. Lipid peroxidation, and RNS production were increased in all tissues studied, especially in those groups that received a combination of drugs. Intoxicated rats exhibited lower antioxidant ability, higher oxidized protein and glutathione levels in plasma with a decreased concentration of α-tocopherol in brain and liver, between 30% and 60% of control. Superoxide dismutase was decreased in liver and brain. Glutathione reductase was inhibited in liver while glutathione peroxidase and transferase were unaffected. Plasma lactate dehydrogenase and γ-glutamyl transpeptidase activities were both increased. The associations of drugs produce more damage than individual administration being the effects observed strongly dependent on the kind of tissue analyzed. In conclusion, the present paper evidenced both the role of the oxidative stress as a mechanism of action of some pesticides and the potential additive effects of a simultaneous exposure to more than one compound. In addition, results suggest a potential contribution of pesticide mixtures to the aetiology of some neurodegenerative diseases.

Original language	English
Journal	Environmental Toxicology and Pharmacology
Volume	28
Issue number	3
Pages (from-to)	465-473
Number of pages	9
ISSN	1382-6689
DOIs	https://doi.org/10.1016/j.etap.2009.07.009
Publication status	Published - 11.2009

Funding

This study was supported by a grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) . We would like to thank Miss Norma Cristalli for her excellent technical assistance and to Norma Tedesco for language revision.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 8 Decent Work and Economic Growth
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.etap.2009.07.009

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title = "Antioxidant defense system in rats simultaneously intoxicated with agrochemicals",

abstract = "The effect of dimethoate, zineb and glyphosate administered alone or in combination on liver, kidney, brain and plasma antioxidant defense system was investigated. Lipid peroxidation, and RNS production were increased in all tissues studied, especially in those groups that received a combination of drugs. Intoxicated rats exhibited lower antioxidant ability, higher oxidized protein and glutathione levels in plasma with a decreased concentration of α-tocopherol in brain and liver, between 30\% and 60\% of control. Superoxide dismutase was decreased in liver and brain. Glutathione reductase was inhibited in liver while glutathione peroxidase and transferase were unaffected. Plasma lactate dehydrogenase and γ-glutamyl transpeptidase activities were both increased. The associations of drugs produce more damage than individual administration being the effects observed strongly dependent on the kind of tissue analyzed. In conclusion, the present paper evidenced both the role of the oxidative stress as a mechanism of action of some pesticides and the potential additive effects of a simultaneous exposure to more than one compound. In addition, results suggest a potential contribution of pesticide mixtures to the aetiology of some neurodegenerative diseases.",

author = "Mariana Astiz and \{de Alaniz\}, \{Mar{\'i}a J.T.\} and Marra, \{Carlos Alberto\}",

note = "Funding Information: This study was supported by a grant from Consejo Nacional de Investigaciones Cient{\'i}ficas y T{\'e}cnicas (CONICET) . We would like to thank Miss Norma Cristalli for her excellent technical assistance and to Norma Tedesco for language revision. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2009",

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doi = "10.1016/j.etap.2009.07.009",

language = "English",

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T1 - Antioxidant defense system in rats simultaneously intoxicated with agrochemicals

AU - Astiz, Mariana

AU - de Alaniz, María J.T.

AU - Marra, Carlos Alberto

N1 - Funding Information: This study was supported by a grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) . We would like to thank Miss Norma Cristalli for her excellent technical assistance and to Norma Tedesco for language revision. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009/11

Y1 - 2009/11

N2 - The effect of dimethoate, zineb and glyphosate administered alone or in combination on liver, kidney, brain and plasma antioxidant defense system was investigated. Lipid peroxidation, and RNS production were increased in all tissues studied, especially in those groups that received a combination of drugs. Intoxicated rats exhibited lower antioxidant ability, higher oxidized protein and glutathione levels in plasma with a decreased concentration of α-tocopherol in brain and liver, between 30% and 60% of control. Superoxide dismutase was decreased in liver and brain. Glutathione reductase was inhibited in liver while glutathione peroxidase and transferase were unaffected. Plasma lactate dehydrogenase and γ-glutamyl transpeptidase activities were both increased. The associations of drugs produce more damage than individual administration being the effects observed strongly dependent on the kind of tissue analyzed. In conclusion, the present paper evidenced both the role of the oxidative stress as a mechanism of action of some pesticides and the potential additive effects of a simultaneous exposure to more than one compound. In addition, results suggest a potential contribution of pesticide mixtures to the aetiology of some neurodegenerative diseases.

AB - The effect of dimethoate, zineb and glyphosate administered alone or in combination on liver, kidney, brain and plasma antioxidant defense system was investigated. Lipid peroxidation, and RNS production were increased in all tissues studied, especially in those groups that received a combination of drugs. Intoxicated rats exhibited lower antioxidant ability, higher oxidized protein and glutathione levels in plasma with a decreased concentration of α-tocopherol in brain and liver, between 30% and 60% of control. Superoxide dismutase was decreased in liver and brain. Glutathione reductase was inhibited in liver while glutathione peroxidase and transferase were unaffected. Plasma lactate dehydrogenase and γ-glutamyl transpeptidase activities were both increased. The associations of drugs produce more damage than individual administration being the effects observed strongly dependent on the kind of tissue analyzed. In conclusion, the present paper evidenced both the role of the oxidative stress as a mechanism of action of some pesticides and the potential additive effects of a simultaneous exposure to more than one compound. In addition, results suggest a potential contribution of pesticide mixtures to the aetiology of some neurodegenerative diseases.

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DO - 10.1016/j.etap.2009.07.009

M3 - Journal articles

AN - SCOPUS:70349570678

SN - 1382-6689

VL - 28

SP - 465

EP - 473

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

IS - 3

ER -

Antioxidant defense system in rats simultaneously intoxicated with agrochemicals

Abstract

Funding

UN SDGs

Research Areas and Centers

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