Antigen-presenting cells and tolerance induction

D. Von Bubnoff, H. De La Salle, J. Weßendorf, S. Koch, D. Hanau, T. Bieber*

*Corresponding author for this work
10 Citations (Scopus)


T cell tolerance induction to foreign and self-antigens has occupied research since the beginning of the understanding of the immune system. Much controversy still exists on this question even though new methods became available to investigate immunoregulatory mechanisms. Antigen-presenting cells play a pivotal role in transferring information from the periphery of the organism to lymphoid organs. There, they initiate not only the activation of naive T cells but seem to deliver important signals which result in T cell unresponsiveness with antigen-specific tolerance induction.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number1
Pages (from-to)2-8
Number of pages7
Publication statusPublished - 2002


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