Antibodies against ENA (Sm, RNP, SSA, SSB)

Gabriela Riemekasten; Jens Y. Humrich; Falk Hiepe

doi:10.1016/B978-0-323-47927-1.00028-1

Antibodies against ENA (Sm, RNP, SSA, SSB)

Gabriela Riemekasten, Jens Y. Humrich, Falk Hiepe

Clinic of Rheumatology

Charite - Universitatsmedizin Berlin

Abstract

Autoantibodies against extractable nuclear antigens (ENAs) describe a subgroup of antinuclear antibodies (ANAs) not reacting with chromatin. They are directed against nuclear proteins that were isolated by salt extraction. ENAs are mainly recognized by sera from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), systemic sclerosis, myositis, and Sjogren’s. Classical autoantigens are Smith-Protein (Sm), ribonucleoproteins (RNP), Robert-Antigen/Sjögren’s A (Ro/SSA), and Lane-Antigen/Sjögren’s B (La/SSB), which are all detectable in sera from SLE patients. It is recommended that the specific antibody designation be used instead of the global term anti-ENA.

Original language	English
Title of host publication	Dubois' Lupus Erythematosus and Related Syndromes
Number of pages	6
Publisher	Elsevier B.V.
Publication date	01.01.2018
Pages	366-371
ISBN (Electronic)	9780323479271
DOIs	https://doi.org/10.1016/B978-0-323-47927-1.00028-1
Publication status	Published - 01.01.2018

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/B978-0-323-47927-1.00028-1

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abstract = "Autoantibodies against extractable nuclear antigens (ENAs) describe a subgroup of antinuclear antibodies (ANAs) not reacting with chromatin. They are directed against nuclear proteins that were isolated by salt extraction. ENAs are mainly recognized by sera from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), systemic sclerosis, myositis, and Sjogren{\textquoteright}s. Classical autoantigens are Smith-Protein (Sm), ribonucleoproteins (RNP), Robert-Antigen/Sj{\"o}gren{\textquoteright}s A (Ro/SSA), and Lane-Antigen/Sj{\"o}gren{\textquoteright}s B (La/SSB), which are all detectable in sera from SLE patients. It is recommended that the specific antibody designation be used instead of the global term anti-ENA.",

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AB - Autoantibodies against extractable nuclear antigens (ENAs) describe a subgroup of antinuclear antibodies (ANAs) not reacting with chromatin. They are directed against nuclear proteins that were isolated by salt extraction. ENAs are mainly recognized by sera from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), systemic sclerosis, myositis, and Sjogren’s. Classical autoantigens are Smith-Protein (Sm), ribonucleoproteins (RNP), Robert-Antigen/Sjögren’s A (Ro/SSA), and Lane-Antigen/Sjögren’s B (La/SSB), which are all detectable in sera from SLE patients. It is recommended that the specific antibody designation be used instead of the global term anti-ENA.

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Antibodies against ENA (Sm, RNP, SSA, SSB)

Abstract

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