Anti-p200 pemphigoid: Diagnosis and treatment of a case presenting as an inflammatory subepidermal blistering disease

Conleth A. Egan*, Carole Yee, Detlef Zillikens, Kim B. Yancey

*Corresponding author for this work
36 Citations (Scopus)

Abstract

Anti-p200 pemphigoid is a recently defined subepidermal immunobullous disease. It is characterized by the binding of circulating IgG autoantibodies to the dermal side of 1 M NaCl split skin and by reactivity of these autoantibodies to a unique 200-kd antigen on immunoblot of dermal extract. On immunoelectron microscopic examination, these autoantibodies deposit at the lamina lucida-lamina densa interface. We describe the clinical, histologic, and immunopathologic features in a patient with anti-p200 pemphigoid, as well as his favorable response to treatment with systemic glucocorticosteroids and dapsone.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
Volume46
Issue number5
Pages (from-to)786-789
Number of pages4
ISSN0190-9622
DOIs
Publication statusPublished - 01.05.2002

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