Anti-laminin 5 mucous membrane pemphigoid

Sandrine Benoit*, Enno Schmidt, Cassian Sitaru, Christian Rose, Matthias Goebeler, Eva B. Bröcker, Detlef Zillikens

*Corresponding author for this work
5 Citations (Scopus)


A 70-year-old patient presented erosions on the oral mucosa and skin, predominantly in perianal and inguinal areas. Histopathologically, subepidermal blistering was observed. By direct immunofluorescence microscopy, linear deposits of IgG and C3 were seen at the dermal-epidermal junction. By indirect immunofluorescence microscopy, binding of IgG autoantibodies to the dermal side of NaCI-split skin was detected. These autoantibodies were shown to target both the non-processed and processed α3- as well as the β3-subunit of laminin 5 by immunoblot analysis using extracellular matrix of cultured human keratinocytes. Based on these results, the diagnosis of an anti-laminin 5 mucous membrane pemphigoid was established. Oral treatment with dapsone, combined with intravenous dexamethasone pulse therapy, led to rapid improvement.

Translated title of the contributionSchleimhautpemphigoid mit autoantikörpern gegen laminin 5
Original languageEnglish
JournalJDDG - Journal of the German Society of Dermatology
Issue number1
Pages (from-to)41-44
Number of pages4
Publication statusPublished - 01.2006

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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