Anti-Ige-antikörper (omalizumab). Therapieindikation in der pädiatrie

Translated title of the contribution: Anti-IgE-antibody (omalizumab). Indication for treatment in pediatrics

M. V. Kopp*, J. Kühr

*Corresponding author for this work


IgE plays a central role in the pathophysiology of allergic disorders. A humanized, monoclonal anti-IgE-antibody in the form of omalizumab is now available, which has a selective effect on the allergic disease process. This antibody binds exclusively to freely circulating IgE. Phase III studies in children and adults consistently showed that treatment with anti-IgE (omalizumab) led to significant reduction of asthma exacerbations and clinical complaints as well as intake of medication for asthma and allergic rhinitis. In another study approach for patients with a food allergy (peanuts), anti-IgE effected a higher tolerated allergic dose in oral provocation tests. The latter effect provides the possibility for preventive intervention in the allergic disease process with anti-IgE.

Translated title of the contributionAnti-IgE-antibody (omalizumab). Indication for treatment in pediatrics
Original languageGerman
JournalMonatsschrift fur Kinderheilkunde
Issue number7
Pages (from-to)782-785
Number of pages4
Publication statusPublished - 07.2004

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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