TY - JOUR
T1 - Anti-Amphiphysin-associated limbic encephalitis in a 72-year-old patient with aortic angiosarcoma
AU - Wagner-Altendorf, Tobias A.
AU - Wandinger, Klaus Peter
AU - Frydrychowicz, Alex
AU - Merseburger, Axel S.
AU - Münte, Thomas F.
N1 - © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2019/3/14
Y1 - 2019/3/14
N2 - Paraneoplastic autoimmune encephalopathic syndromes have been described most often in association with small cell lung cancer or breast cancer, tumours of the ovaries, testes, lymphoma and thymoma. Antibodies associated with paraneoplastic encephalopathies are, among others, anti-Hu, anti-Ma2 and, in part, anti-N-methyl-D-aspartate(NMDA)-receptor antibodies. Here, we present the case of a 72-year-old patient hospitalised due to progressive cognitive decline and disorientation. Diagnostic workup revealed paraneoplastic anti-amphiphysin associated limbic encephalitis on the basis of an aortic angiosarcoma with metastases to kidney, muscle and bones. Highly aggressive chemotherapy as well as immunosuppressive therapy and cytoreductive laparoscopic nephrectomy were initiated. However, follow-up revealed further tumour progress and a worsening of neurological symptoms.
AB - Paraneoplastic autoimmune encephalopathic syndromes have been described most often in association with small cell lung cancer or breast cancer, tumours of the ovaries, testes, lymphoma and thymoma. Antibodies associated with paraneoplastic encephalopathies are, among others, anti-Hu, anti-Ma2 and, in part, anti-N-methyl-D-aspartate(NMDA)-receptor antibodies. Here, we present the case of a 72-year-old patient hospitalised due to progressive cognitive decline and disorientation. Diagnostic workup revealed paraneoplastic anti-amphiphysin associated limbic encephalitis on the basis of an aortic angiosarcoma with metastases to kidney, muscle and bones. Highly aggressive chemotherapy as well as immunosuppressive therapy and cytoreductive laparoscopic nephrectomy were initiated. However, follow-up revealed further tumour progress and a worsening of neurological symptoms.
UR - http://www.scopus.com/inward/record.url?scp=85062906598&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/antiamphiphysinassociated-limbic-encephalitis-72yearold-patient-aortic-angiosarcoma
U2 - 10.1136/bcr-2018-226798
DO - 10.1136/bcr-2018-226798
M3 - Journal articles
C2 - 30872337
AN - SCOPUS:85062906598
SN - 1757-790X
VL - 12
SP - e226798
JO - BMJ Case Reports
JF - BMJ Case Reports
IS - 3
M1 - e226798
ER -
