Animal models for autoimmune bullous dermatoses

Katja Bieber; Shijie Sun; Norito Ishii; Michael Kasperkiewicz; Enno Schmidt; Misa Hirose; Jürgen Westermann; Xinhua Yu; Detlef Zillikens; Ralf J. Ludwig

doi:10.1111/j.1600-0625.2009.00948.x

Animal models for autoimmune bullous dermatoses

Katja Bieber, Shijie Sun, Norito Ishii, Michael Kasperkiewicz, Enno Schmidt, Misa Hirose, Jürgen Westermann, Xinhua Yu, Detlef Zillikens, Ralf J. Ludwig^*

^*Corresponding author for this work

Airway Research Center North

38 Citations (Scopus)

Abstract

Autoimmune bullous dermatoses are a group of severe diseases, which are clinically characterized by blisters and erosions of skin and/or mucous membranes. In order to investigate the pathogenesis of these potentially life-threatening diseases and to develop more specific therapeutic approaches, animal models have been developed that aim to reproduce the clinical, histological and immunopathological findings. We here review established and novel animal models of autoimmune skin blistering diseases and discuss their applications and limitations.

Original language	English
Journal	Experimental Dermatology
Volume	19
Issue number	1
Pages (from-to)	2-11
Number of pages	10
ISSN	0906-6705
DOIs	https://doi.org/10.1111/j.1600-0625.2009.00948.x
Publication status	Published - 01.01.2010

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10.1111/j.1600-0625.2009.00948.x

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AU - Ishii, Norito

AU - Kasperkiewicz, Michael

AU - Schmidt, Enno

AU - Hirose, Misa

AU - Westermann, Jürgen

AU - Yu, Xinhua

AU - Zillikens, Detlef

AU - Ludwig, Ralf J.

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AB - Autoimmune bullous dermatoses are a group of severe diseases, which are clinically characterized by blisters and erosions of skin and/or mucous membranes. In order to investigate the pathogenesis of these potentially life-threatening diseases and to develop more specific therapeutic approaches, animal models have been developed that aim to reproduce the clinical, histological and immunopathological findings. We here review established and novel animal models of autoimmune skin blistering diseases and discuss their applications and limitations.

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Animal models for autoimmune bullous dermatoses

Abstract

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