TY - JOUR
T1 - Animal models for autoimmune bullous dermatoses
AU - Bieber, Katja
AU - Sun, Shijie
AU - Ishii, Norito
AU - Kasperkiewicz, Michael
AU - Schmidt, Enno
AU - Hirose, Misa
AU - Westermann, Jürgen
AU - Yu, Xinhua
AU - Zillikens, Detlef
AU - Ludwig, Ralf J.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Autoimmune bullous dermatoses are a group of severe diseases, which are clinically characterized by blisters and erosions of skin and/or mucous membranes. In order to investigate the pathogenesis of these potentially life-threatening diseases and to develop more specific therapeutic approaches, animal models have been developed that aim to reproduce the clinical, histological and immunopathological findings. We here review established and novel animal models of autoimmune skin blistering diseases and discuss their applications and limitations.
AB - Autoimmune bullous dermatoses are a group of severe diseases, which are clinically characterized by blisters and erosions of skin and/or mucous membranes. In order to investigate the pathogenesis of these potentially life-threatening diseases and to develop more specific therapeutic approaches, animal models have been developed that aim to reproduce the clinical, histological and immunopathological findings. We here review established and novel animal models of autoimmune skin blistering diseases and discuss their applications and limitations.
UR - http://www.scopus.com/inward/record.url?scp=72549096651&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2009.00948.x
DO - 10.1111/j.1600-0625.2009.00948.x
M3 - Scientific review articles
C2 - 19702839
AN - SCOPUS:72549096651
SN - 0906-6705
VL - 19
SP - 2
EP - 11
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 1
ER -
