Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism

S. Boye; M. Voß; H. Scholand-Engler; F. Binkowski; H. Gehring; U. H. Melchert; K. M. Oltmanns

doi:10.1007/978-3-642-03885-3_244

Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism

S. Boye^*, M. Voß, H. Scholand-Engler, F. Binkowski, H. Gehring, U. H. Melchert, K. M. Oltmanns

^*Corresponding author for this work

Abstract

Several centres worldwide have established con-trolled hypoxemia studies (CHS) for testing and calibrating pulse oximeters. Since the brain is, compared to the rest of the body, a highly demanding organ that requires nearly 20 % of the body's total oxygen supply, a period of hypoxemia may reduce the content of high energy phosphates such as phosphocreatine (PCr) with constant levels of adenosine triphosphate (ATP). To prove this hypothesis a controlled 30 minute hypoxemic state of 70 to75 % arterial oxygen saturation was induced in healthy subjects. ³¹P magnetic resonance spectroscopy (³¹P-MRS) performed in a 3Tesla (T)-MR-scanner was used for high energy phosphates measurement. The study protocol was based on a randomised trial including two groups of male volunteers, one with normal weight and one with a body mass index higher than 30 kg/m² in such a way that each person served as his own control in one session with normoxemia and one with hypoxemia. The knowledge of physiological adjustment to a hypoxemia as well as the volunteer management is the basis for a safe procedure.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
Editors	Olaf Dössel, Wolfgang C. Schlegel
Number of pages	3
Publisher	Springer Berlin Heidelberg
Publication date	2009
Pages	880-882
ISBN (Print)	978-3-642-03884-6
ISBN (Electronic)	978-3-642-03885-3
DOIs	https://doi.org/10.1007/978-3-642-03885-3_244
Publication status	Published - 2009
Event	World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich , Germany Duration: 07.09.2009 → 12.09.2009 Conference number: 81644

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1007/978-3-642-03885-3_244

Cite this

Boye, S., Voß, M., Scholand-Engler, H., Binkowski, F., Gehring, H., Melchert, U. H., & Oltmanns, K. M. (2009). Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism. In O. Dössel, & W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany (pp. 880-882). (IFMBE Proceedings). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-03885-3_244

Boye, S. ; Voß, M. ; Scholand-Engler, H. et al. / Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism. World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. editor / Olaf Dössel ; Wolfgang C. Schlegel. Springer Berlin Heidelberg, 2009. pp. 880-882 (IFMBE Proceedings).

@inproceedings{7b3ec94a94664ad087ec6881cb22aff9,

title = "Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism",

abstract = "Several centres worldwide have established con-trolled hypoxemia studies (CHS) for testing and calibrating pulse oximeters. Since the brain is, compared to the rest of the body, a highly demanding organ that requires nearly 20 \% of the body's total oxygen supply, a period of hypoxemia may reduce the content of high energy phosphates such as phosphocreatine (PCr) with constant levels of adenosine triphosphate (ATP). To prove this hypothesis a controlled 30 minute hypoxemic state of 70 to75 \% arterial oxygen saturation was induced in healthy subjects. 31P magnetic resonance spectroscopy (31P-MRS) performed in a 3Tesla (T)-MR-scanner was used for high energy phosphates measurement. The study protocol was based on a randomised trial including two groups of male volunteers, one with normal weight and one with a body mass index higher than 30 kg/m2 in such a way that each person served as his own control in one session with normoxemia and one with hypoxemia. The knowledge of physiological adjustment to a hypoxemia as well as the volunteer management is the basis for a safe procedure.",

author = "S. Boye and M. Vo{\ss} and H. Scholand-Engler and F. Binkowski and H. Gehring and Melchert, \{U. H.\} and Oltmanns, \{K. M.\}",

year = "2009",

doi = "10.1007/978-3-642-03885-3\_244",

language = "English",

isbn = "978-3-642-03884-6",

series = "IFMBE Proceedings",

publisher = "Springer Berlin Heidelberg",

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editor = "D{\"o}ssel, \{Olaf \} and \{C. Schlegel\}, \{Wolfgang \}",

booktitle = "World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany",

note = "World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging ; Conference date: 07-09-2009 Through 12-09-2009",

}

Boye, S, Voß, M, Scholand-Engler, H, Binkowski, F, Gehring, H, Melchert, UH & Oltmanns, KM 2009, Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism. in O Dössel & W C. Schlegel (eds), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, Springer Berlin Heidelberg, pp. 880-882, World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging, Munich , Bavaria, Germany, 07.09.09. https://doi.org/10.1007/978-3-642-03885-3_244

Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism. / Boye, S.; Voß, M.; Scholand-Engler, H. et al.
World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. ed. / Olaf Dössel; Wolfgang C. Schlegel. Springer Berlin Heidelberg, 2009. p. 880-882 (IFMBE Proceedings).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

TY - GEN

T1 - Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism

AU - Boye, S.

AU - Voß, M.

AU - Scholand-Engler, H.

AU - Binkowski, F.

AU - Gehring, H.

AU - Melchert, U. H.

AU - Oltmanns, K. M.

N1 - Conference code: 81644

PY - 2009

Y1 - 2009

N2 - Several centres worldwide have established con-trolled hypoxemia studies (CHS) for testing and calibrating pulse oximeters. Since the brain is, compared to the rest of the body, a highly demanding organ that requires nearly 20 % of the body's total oxygen supply, a period of hypoxemia may reduce the content of high energy phosphates such as phosphocreatine (PCr) with constant levels of adenosine triphosphate (ATP). To prove this hypothesis a controlled 30 minute hypoxemic state of 70 to75 % arterial oxygen saturation was induced in healthy subjects. 31P magnetic resonance spectroscopy (31P-MRS) performed in a 3Tesla (T)-MR-scanner was used for high energy phosphates measurement. The study protocol was based on a randomised trial including two groups of male volunteers, one with normal weight and one with a body mass index higher than 30 kg/m2 in such a way that each person served as his own control in one session with normoxemia and one with hypoxemia. The knowledge of physiological adjustment to a hypoxemia as well as the volunteer management is the basis for a safe procedure.

AB - Several centres worldwide have established con-trolled hypoxemia studies (CHS) for testing and calibrating pulse oximeters. Since the brain is, compared to the rest of the body, a highly demanding organ that requires nearly 20 % of the body's total oxygen supply, a period of hypoxemia may reduce the content of high energy phosphates such as phosphocreatine (PCr) with constant levels of adenosine triphosphate (ATP). To prove this hypothesis a controlled 30 minute hypoxemic state of 70 to75 % arterial oxygen saturation was induced in healthy subjects. 31P magnetic resonance spectroscopy (31P-MRS) performed in a 3Tesla (T)-MR-scanner was used for high energy phosphates measurement. The study protocol was based on a randomised trial including two groups of male volunteers, one with normal weight and one with a body mass index higher than 30 kg/m2 in such a way that each person served as his own control in one session with normoxemia and one with hypoxemia. The knowledge of physiological adjustment to a hypoxemia as well as the volunteer management is the basis for a safe procedure.

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U2 - 10.1007/978-3-642-03885-3_244

DO - 10.1007/978-3-642-03885-3_244

M3 - Conference contribution

SN - 978-3-642-03884-6

T3 - IFMBE Proceedings

SP - 880

EP - 882

BT - World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany

A2 - Dössel, Olaf

A2 - C. Schlegel, Wolfgang

PB - Springer Berlin Heidelberg

T2 - World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging

Y2 - 7 September 2009 through 12 September 2009

ER -

Boye S, Voß M, Scholand-Engler H, Binkowski F, Gehring H, Melchert UH et al. Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism. In Dössel O, C. Schlegel W, editors, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. Springer Berlin Heidelberg. 2009. p. 880-882. (IFMBE Proceedings). doi: 10.1007/978-3-642-03885-3_244

Anesthesiological Management in a Non-accessible Environment Preparation of Volunteers for Investigations with Controlled Hypoxemia in a 3 Tesla Magnetic Field for Assessing Cerebral Energy Metabolism

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