Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

María Teruel*, Carmen P. Simeon, Jasper Broen, Madelon C. Vonk, Patricia Carreira, Maria T. Camps, Rosa García-Portales, Esmeralda Delgado-Frías, Maria Gallego, Gerard Espinosa, Lorenzo Beretta, Paolo Airó, Claudio Lunardi, Gabriela Riemekasten, Torsten Witte, Thomas Krieg, Alexander Kreuter, Jörg H.W. Distler, Nicolas Hunzelmann, Bobby P. KoelemanAlexandre E. Voskuyl, Annemie J. Schuerwegh, Miguel T. González-Gay, Timothy R.D.J. Radstake, Javier Martin, Norberto Ortego-Centeno, José Luis Callejas, Raquel Ríos, Nuria Navarrete, Antonio Garcia, Antonio Fernández-Nebro, María F. González-Escribano, Julio Sánchez-Román, M. Jesús Castillo, M. Ángeles Aguirre, Inmaculada Gómez-Gracia, Benjamín Fernández-Gutiérrez, Luis Rodríguez-Rodríguez, Esther Vicente, Mónica Fernández Castro, José Luis Andreu, Paloma García de la Peña, Francisco Javier López-Longo, Lina Martínez-Estupiñán, Anna Pros, Vicente Fonollosa, Carlos Tolosa, Mónica Rodríguez Carballeira, Ivan Castellví, Francisco Javier Narváez, Francisco Javier Blanco-García, Natividad Oreiro, María Ángeles Robles, María Victoria Egurbide, Luis SáezComet, Ricardo Blanco, Bernardino Díaz, Luis Trapiella, Federico Díaz, Vanesa Hernández, Emma Beltrán, José Andrés Román-Ivorra

*Corresponding author for this work
10 Citations (Scopus)


Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.

Original languageEnglish
Article numberR154
JournalArthritis Research and Therapy
Issue number3
Publication statusPublished - 25.06.2012

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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