Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

María Teruel; Carmen P. Simeon; Jasper Broen; Madelon C. Vonk; Patricia Carreira; Maria T. Camps; Rosa García-Portales; Esmeralda Delgado-Frías; Maria Gallego; Gerard Espinosa; Lorenzo Beretta; Paolo Airó; Claudio Lunardi; Gabriela Riemekasten; Torsten Witte; Thomas Krieg; Alexander Kreuter; Jörg H.W. Distler; Nicolas Hunzelmann; Bobby P. Koeleman; Alexandre E. Voskuyl; Annemie J. Schuerwegh; Miguel T. González-Gay; Timothy R.D.J. Radstake; Javier Martin; Norberto Ortego-Centeno; José Luis Callejas; Raquel Ríos; Nuria Navarrete; Antonio Garcia; Antonio Fernández-Nebro; María F. González-Escribano; Julio Sánchez-Román; M. Jesús Castillo; M. Ángeles Aguirre; Inmaculada Gómez-Gracia; Benjamín Fernández-Gutiérrez; Luis Rodríguez-Rodríguez; Esther Vicente; Mónica Fernández Castro; José Luis Andreu; Paloma García de la Peña; Francisco Javier López-Longo; Lina Martínez-Estupiñán; Anna Pros; Vicente Fonollosa; Carlos Tolosa; Mónica Rodríguez Carballeira; Ivan Castellví; Francisco Javier Narváez; Francisco Javier Blanco-García; Natividad Oreiro; María Ángeles Robles; María Victoria Egurbide; Luis SáezComet; Ricardo Blanco; Bernardino Díaz; Luis Trapiella; Federico Díaz; Vanesa Hernández; Emma Beltrán; José Andrés Román-Ivorra

doi:10.1186/ar3890

Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

María Teruel^*, Carmen P. Simeon, Jasper Broen, Madelon C. Vonk, Patricia Carreira, Maria T. Camps, Rosa García-Portales, Esmeralda Delgado-Frías, Maria Gallego, Gerard Espinosa, Lorenzo Beretta, Paolo Airó, Claudio Lunardi, Gabriela Riemekasten, Torsten Witte, Thomas Krieg, Alexander Kreuter, Jörg H.W. Distler, Nicolas Hunzelmann, Bobby P. KoelemanAlexandre E. Voskuyl, Annemie J. Schuerwegh, Miguel T. González-Gay, Timothy R.D.J. Radstake, Javier Martin, Norberto Ortego-Centeno, José Luis Callejas, Raquel Ríos, Nuria Navarrete, Antonio Garcia, Antonio Fernández-Nebro, María F. González-Escribano, Julio Sánchez-Román, M. Jesús Castillo, M. Ángeles Aguirre, Inmaculada Gómez-Gracia, Benjamín Fernández-Gutiérrez, Luis Rodríguez-Rodríguez, Esther Vicente, Mónica Fernández Castro, José Luis Andreu, Paloma García de la Peña, Francisco Javier López-Longo, Lina Martínez-Estupiñán, Anna Pros, Vicente Fonollosa, Carlos Tolosa, Mónica Rodríguez Carballeira, Ivan Castellví, Francisco Javier Narváez, Francisco Javier Blanco-García, Natividad Oreiro, María Ángeles Robles, María Victoria Egurbide, Luis SáezComet, Ricardo Blanco, Bernardino Díaz, Luis Trapiella, Federico Díaz, Vanesa Hernández, Emma Beltrán, José Andrés Román-Ivorra

^*Corresponding author for this work

Clinic of Rheumatology

10 Citations (Scopus)

Abstract

Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.

Original language	English
Article number	R154
Journal	Arthritis Research and Therapy
Volume	14
Issue number	3
ISSN	1478-6354
DOIs	https://doi.org/10.1186/ar3890
Publication status	Published - 25.06.2012

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/ar3890

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Teruel, M., Simeon, C. P., Broen, J., Vonk, M. C., Carreira, P., Camps, M. T., García-Portales, R., Delgado-Frías, E., Gallego, M., Espinosa, G., Beretta, L., Airó, P., Lunardi, C., Riemekasten, G., Witte, T., Krieg, T., Kreuter, A., Distler, J. H. W., Hunzelmann, N., ... Román-Ivorra, J. A. (2012). Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Arthritis Research and Therapy, 14(3), Article R154. https://doi.org/10.1186/ar3890

@article{fd12619d50e5487886b7f6d64ceaf170,

title = "Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis",

abstract = "Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.",

author = "Mar{\'i}a Teruel and Simeon, {Carmen P.} and Jasper Broen and Vonk, {Madelon C.} and Patricia Carreira and Camps, {Maria T.} and Rosa Garc{\'i}a-Portales and Esmeralda Delgado-Fr{\'i}as and Maria Gallego and Gerard Espinosa and Lorenzo Beretta and Paolo Air{\'o} and Claudio Lunardi and Gabriela Riemekasten and Torsten Witte and Thomas Krieg and Alexander Kreuter and Distler, {J{\"o}rg H.W.} and Nicolas Hunzelmann and Koeleman, {Bobby P.} and Voskuyl, {Alexandre E.} and Schuerwegh, {Annemie J.} and Gonz{\'a}lez-Gay, {Miguel T.} and Radstake, {Timothy R.D.J.} and Javier Martin and Norberto Ortego-Centeno and Callejas, {Jos{\'e} Luis} and Raquel R{\'i}os and Nuria Navarrete and Antonio Garcia and Antonio Fern{\'a}ndez-Nebro and Gonz{\'a}lez-Escribano, {Mar{\'i}a F.} and Julio S{\'a}nchez-Rom{\'a}n and Castillo, {M. Jes{\'u}s} and Aguirre, {M. {\'A}ngeles} and Inmaculada G{\'o}mez-Gracia and Benjam{\'i}n Fern{\'a}ndez-Guti{\'e}rrez and Luis Rodr{\'i}guez-Rodr{\'i}guez and Esther Vicente and Castro, {M{\'o}nica Fern{\'a}ndez} and Andreu, {Jos{\'e} Luis} and {de la Pe{\~n}a}, {Paloma Garc{\'i}a} and L{\'o}pez-Longo, {Francisco Javier} and Lina Mart{\'i}nez-Estupi{\~n}{\'a}n and Anna Pros and Vicente Fonollosa and Carlos Tolosa and Carballeira, {M{\'o}nica Rodr{\'i}guez} and Ivan Castellv{\'i} and Narv{\'a}ez, {Francisco Javier} and Blanco-Garc{\'i}a, {Francisco Javier} and Natividad Oreiro and Robles, {Mar{\'i}a {\'A}ngeles} and Egurbide, {Mar{\'i}a Victoria} and Luis S{\'a}ezComet and Ricardo Blanco and Bernardino D{\'i}az and Luis Trapiella and Federico D{\'i}az and Vanesa Hern{\'a}ndez and Emma Beltr{\'a}n and Rom{\'a}n-Ivorra, {Jos{\'e} Andr{\'e}s}",

year = "2012",

month = jun,

day = "25",

doi = "10.1186/ar3890",

language = "English",

volume = "14",

journal = "Arthritis Research and Therapy",

issn = "1478-6354",

number = "3",

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Teruel, M, Simeon, CP, Broen, J, Vonk, MC, Carreira, P, Camps, MT, García-Portales, R, Delgado-Frías, E, Gallego, M, Espinosa, G, Beretta, L, Airó, P, Lunardi, C, Riemekasten, G, Witte, T, Krieg, T, Kreuter, A, Distler, JHW, Hunzelmann, N, Koeleman, BP, Voskuyl, AE, Schuerwegh, AJ, González-Gay, MT, Radstake, TRDJ, Martin, J, Ortego-Centeno, N, Callejas, JL, Ríos, R, Navarrete, N, Garcia, A, Fernández-Nebro, A, González-Escribano, MF, Sánchez-Román, J, Castillo, MJ, Aguirre, MÁ, Gómez-Gracia, I, Fernández-Gutiérrez, B, Rodríguez-Rodríguez, L, Vicente, E, Castro, MF, Andreu, JL, de la Peña, PG, López-Longo, FJ, Martínez-Estupiñán, L, Pros, A, Fonollosa, V, Tolosa, C, Carballeira, MR, Castellví, I, Narváez, FJ, Blanco-García, FJ, Oreiro, N, Robles, MÁ, Egurbide, MV, SáezComet, L, Blanco, R, Díaz, B, Trapiella, L, Díaz, F, Hernández, V, Beltrán, E & Román-Ivorra, JA 2012, 'Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis', Arthritis Research and Therapy, vol. 14, no. 3, R154. https://doi.org/10.1186/ar3890

TY - JOUR

T1 - Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

AU - Teruel, María

AU - Simeon, Carmen P.

AU - Broen, Jasper

AU - Vonk, Madelon C.

AU - Carreira, Patricia

AU - Camps, Maria T.

AU - García-Portales, Rosa

AU - Delgado-Frías, Esmeralda

AU - Gallego, Maria

AU - Espinosa, Gerard

AU - Beretta, Lorenzo

AU - Airó, Paolo

AU - Lunardi, Claudio

AU - Riemekasten, Gabriela

AU - Witte, Torsten

AU - Krieg, Thomas

AU - Kreuter, Alexander

AU - Distler, Jörg H.W.

AU - Hunzelmann, Nicolas

AU - Koeleman, Bobby P.

AU - Voskuyl, Alexandre E.

AU - Schuerwegh, Annemie J.

AU - González-Gay, Miguel T.

AU - Radstake, Timothy R.D.J.

AU - Martin, Javier

AU - Ortego-Centeno, Norberto

AU - Callejas, José Luis

AU - Ríos, Raquel

AU - Navarrete, Nuria

AU - Garcia, Antonio

AU - Fernández-Nebro, Antonio

AU - González-Escribano, María F.

AU - Sánchez-Román, Julio

AU - Castillo, M. Jesús

AU - Aguirre, M. Ángeles

AU - Gómez-Gracia, Inmaculada

AU - Fernández-Gutiérrez, Benjamín

AU - Rodríguez-Rodríguez, Luis

AU - Vicente, Esther

AU - Castro, Mónica Fernández

AU - Andreu, José Luis

AU - de la Peña, Paloma García

AU - López-Longo, Francisco Javier

AU - Martínez-Estupiñán, Lina

AU - Pros, Anna

AU - Fonollosa, Vicente

AU - Tolosa, Carlos

AU - Carballeira, Mónica Rodríguez

AU - Castellví, Ivan

AU - Narváez, Francisco Javier

AU - Blanco-García, Francisco Javier

AU - Oreiro, Natividad

AU - Robles, María Ángeles

AU - Egurbide, María Victoria

AU - SáezComet, Luis

AU - Blanco, Ricardo

AU - Díaz, Bernardino

AU - Trapiella, Luis

AU - Díaz, Federico

AU - Hernández, Vanesa

AU - Beltrán, Emma

AU - Román-Ivorra, José Andrés

PY - 2012/6/25

Y1 - 2012/6/25

N2 - Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.

AB - Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.

UR - http://www.scopus.com/inward/record.url?scp=84862597986&partnerID=8YFLogxK

U2 - 10.1186/ar3890

DO - 10.1186/ar3890

M3 - Journal articles

C2 - 22731751

AN - SCOPUS:84862597986

SN - 1478-6354

VL - 14

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

IS - 3

M1 - R154

ER -

Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

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