TY - JOUR
T1 - Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome
AU - Wang, Jun
AU - Kalyan, Shirin
AU - Steck, Natalie
AU - Turner, Leslie M.
AU - Harr, Bettina
AU - Künzel, Sven
AU - Vallier, Marie
AU - Häsler, Robert
AU - Franke, Andre
AU - Oberg, Hans Heinrich
AU - Ibrahim, Saleh M.
AU - Grassl, Guntram A.
AU - Kabelitz, Dieter
AU - Baines, John F.
N1 - Funding Information:
We thank Silke Carstensen, Jan Schubert, Katja Cloppenborg-Schmidt, Dorina Ölsner and Tanja Wesse for excellent technical assistance; Kim Steige and Miriam Linnenbrink for assistance in the field; Christine Pfeifle and Pankaj Barua for assistance in mouse husbandry; and Arne Nolte and Fabian Staubach for helpful discussion. This work was supported by the Deutsche Forschungsgemeinschaft (DFG) Excellence Cluster 306 ‘Inflammation at Interfaces’ and the Max Planck Society.
PY - 2015/3/4
Y1 - 2015/3/4
N2 - Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the 'hologenomic basis of speciation'. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in addition to hybrids generated in the lab. Hybrid mice display widespread transgressive phenotypes (that is, exceed or fall short of parental values) in a variety of measures of bacterial community structure, which reveals the importance of stabilizing selection operating on the intestinal microbiome within species. Further genetic and immunological analyses reveal genetic incompatibilities, aberrant immune gene expression and increased intestinal pathology associated with altered community structure among hybrids. These results provide unique insight into the consequences of evolutionary divergence in a vertebrate 'hologenome', which may be an unrecognized contributing factor to reproductive isolation in this taxonomic group.
AB - Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the 'hologenomic basis of speciation'. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in addition to hybrids generated in the lab. Hybrid mice display widespread transgressive phenotypes (that is, exceed or fall short of parental values) in a variety of measures of bacterial community structure, which reveals the importance of stabilizing selection operating on the intestinal microbiome within species. Further genetic and immunological analyses reveal genetic incompatibilities, aberrant immune gene expression and increased intestinal pathology associated with altered community structure among hybrids. These results provide unique insight into the consequences of evolutionary divergence in a vertebrate 'hologenome', which may be an unrecognized contributing factor to reproductive isolation in this taxonomic group.
UR - http://www.scopus.com/inward/record.url?scp=84924203445&partnerID=8YFLogxK
U2 - 10.1038/ncomms7440
DO - 10.1038/ncomms7440
M3 - Journal articles
C2 - 25737238
AN - SCOPUS:84924203445
SN - 1751-8628
VL - 6
JO - Nature Communications
JF - Nature Communications
M1 - 6440
ER -
