Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia

Katrin Zimmermann, Heike Görgens, David Bräuer, Franziska Einsle, Barbara Noack, Stephanie von Kannen, Maria Grossmann, Jürgen Hoyer, Alexander Strobel, Volker Köllner, Kerstin Weidner, Andreas Ziegler, Claudia Hemmelmann, Hans K. Schackert

Abstract

A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as agoraphobia with/without panic disorder. Studies in humans, however, provided inconclusive evidence on the association of GRP and GRPR variations in agoraphobia with/without panic disorder. Based on these findings, we investigated whether GRP and GRPR variants are associated with agoraphobia. Mental disorders were assessed via the Munich-Composite International Diagnostic Interview (M-CIDI) in 95 patients with agoraphobia with/without panic disorder and 119 controls without any mental disorders. A complete sequence analysis of GRP and GRPR was performed in all participants. We found no association of 16 GRP and 7 GRPR variants with agoraphobia with/without panic disorder.

Original languageEnglish
JournalPsychiatric Genetics
Volume24
Issue number5
Pages (from-to)232-233
Number of pages2
ISSN0955-8829
DOIs
Publication statusPublished - 01.10.2014

Fingerprint

Dive into the research topics of 'Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia'. Together they form a unique fingerprint.

Cite this