TY - JOUR
T1 - Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia
AU - Zimmermann, Katrin
AU - Görgens, Heike
AU - Bräuer, David
AU - Einsle, Franziska
AU - Noack, Barbara
AU - von Kannen, Stephanie
AU - Grossmann, Maria
AU - Hoyer, Jürgen
AU - Strobel, Alexander
AU - Köllner, Volker
AU - Weidner, Kerstin
AU - Ziegler, Andreas
AU - Hemmelmann, Claudia
AU - Schackert, Hans K.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as agoraphobia with/without panic disorder. Studies in humans, however, provided inconclusive evidence on the association of GRP and GRPR variations in agoraphobia with/without panic disorder. Based on these findings, we investigated whether GRP and GRPR variants are associated with agoraphobia. Mental disorders were assessed via the Munich-Composite International Diagnostic Interview (M-CIDI) in 95 patients with agoraphobia with/without panic disorder and 119 controls without any mental disorders. A complete sequence analysis of GRP and GRPR was performed in all participants. We found no association of 16 GRP and 7 GRPR variants with agoraphobia with/without panic disorder.
AB - A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as agoraphobia with/without panic disorder. Studies in humans, however, provided inconclusive evidence on the association of GRP and GRPR variations in agoraphobia with/without panic disorder. Based on these findings, we investigated whether GRP and GRPR variants are associated with agoraphobia. Mental disorders were assessed via the Munich-Composite International Diagnostic Interview (M-CIDI) in 95 patients with agoraphobia with/without panic disorder and 119 controls without any mental disorders. A complete sequence analysis of GRP and GRPR was performed in all participants. We found no association of 16 GRP and 7 GRPR variants with agoraphobia with/without panic disorder.
UR - http://www.scopus.com/inward/record.url?scp=85028219151&partnerID=8YFLogxK
U2 - 10.1097/YPG.0000000000000038
DO - 10.1097/YPG.0000000000000038
M3 - Letters
C2 - 24912045
AN - SCOPUS:85028219151
SN - 0955-8829
VL - 24
SP - 232
EP - 233
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 5
ER -
