Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis

Jeffrey C. Edberg; Eduardo Wainstein; Jianming Wu; Elena Csernok; Michael C. Sneller; Gary S. Hoffman; Edward C. Keystone; Wolfgang L. Gross; Robert P. Kimberly

Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis

Jeffrey C. Edberg, Eduardo Wainstein, Jianming Wu, Elena Csernok, Michael C. Sneller, Gary S. Hoffman, Edward C. Keystone, Wolfgang L. Gross, Robert P. Kimberly^*

^*Corresponding author for this work

Clinic of Rheumatology

58 Citations (Scopus)

Abstract

Fcγ receptors (FcγRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcγR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcγR (FcγRIIa-H131/R131 and FcγRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.

Original language	English
Journal	Experimental and Clinical Immunogenetics
Volume	14
Issue number	3
Pages (from-to)	183-195
Number of pages	13
ISSN	0254-9670
Publication status	Published - 01.1998

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Cite this

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title = "Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis",

abstract = "Fcγ receptors (FcγRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcγR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcγR (FcγRIIa-H131/R131 and FcγRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.",

author = "Edberg, \{Jeffrey C.\} and Eduardo Wainstein and Jianming Wu and Elena Csernok and Sneller, \{Michael C.\} and Hoffman, \{Gary S.\} and Keystone, \{Edward C.\} and Gross, \{Wolfgang L.\} and Kimberly, \{Robert P.\}",

year = "1998",

month = jan,

language = "English",

volume = "14",

pages = "183--195",

journal = "Experimental and Clinical Immunogenetics",

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TY - JOUR

T1 - Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis

AU - Edberg, Jeffrey C.

AU - Wainstein, Eduardo

AU - Wu, Jianming

AU - Csernok, Elena

AU - Sneller, Michael C.

AU - Hoffman, Gary S.

AU - Keystone, Edward C.

AU - Gross, Wolfgang L.

AU - Kimberly, Robert P.

PY - 1998/1

Y1 - 1998/1

N2 - Fcγ receptors (FcγRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcγR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcγR (FcγRIIa-H131/R131 and FcγRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.

AB - Fcγ receptors (FcγRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcγR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcγR (FcγRIIa-H131/R131 and FcγRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.

UR - https://www.scopus.com/pages/publications/0031283050

M3 - Journal articles

C2 - 9493787

AN - SCOPUS:0031283050

SN - 0254-9670

VL - 14

SP - 183

EP - 195

JO - Experimental and Clinical Immunogenetics

JF - Experimental and Clinical Immunogenetics

IS - 3

ER -

Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis

Abstract

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