Translated title of the contribution: Anal canal carcinoma: Diagnosis - therapy - prognosis

G. G. Grabenbauer, N. Wolf, J. Dunst, R. Sauer

10 Citations (Scopus)


78 patients with anal canal carcinoma were treated between 1970 and 1988 at the University Hospital Erlangen. 48 Patients (35 women, 13 men) were treated by surgery alone, 44/48 by abdominoperineal resection, 4/48 by local excision. Median age was 63 years, median follow-up 8.5 years. The overall local recurrence rate was 16.7%, the overall five-year-survival was 51%. 30 patients received a combined radio-chemotherapy. The small pelvis was treated with a.-p./p.-a. fields up to a total dose between 42 and 50 Gy. Two courses of chemotherapy consisting of 5-FU (800 to 1000 mg/m2 days 1 to 4 and 29 to 32) and Mitomycin C (10mg/m2 days 1 and 29) were administered. Two months after completion of treatment 83% had a biopsy proven complete remission. After a median follow-up of 15 months 87% are alive with NED, 74% are continent. The combined regimen of radio-chemotherapy is considered as the treatment of the choice for anal canal carcinoma. Abdomionoperineal resection is only performed in patients with non response or local recurrent disease.

Translated title of the contributionAnal canal carcinoma: Diagnosis - therapy - prognosis
Original languageGerman
JournalStrahlentherapie und Onkologie
Issue number12
Pages (from-to)829-836
Number of pages8
Publication statusPublished - 1989


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