Abstract
The ab initio computation of the molecular envelopes of two proteins exclusively from their corresponding diffraction amplitudes demonstrates that an efficient and inherently parallel evolutionary search algorithm can assist in the direct phasing of macromolecules for which almost no a priori structural information is available. The applicability of this evolutionary computational approach is general and should not be limited to the examples described nor to extremes of data resolution, symmetry or structural size.
| Original language | English |
|---|---|
| Journal | Acta Crystallographica Section A: Foundations of Crystallography |
| Volume | 57 |
| Issue number | 3 |
| Pages (from-to) | 351-358 |
| Number of pages | 8 |
| ISSN | 0108-7673 |
| DOIs | |
| Publication status | Published - 01.05.2001 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
Fingerprint
Dive into the research topics of 'An evolutionary computational approach to the phase problem in macromolecular X-ray crystallography'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver