An emerging concept of vascular salt sensitivity

Kristina Kusche-Vihrog, Hans Oberleithner*

*Corresponding author for this work
26 Citations (Scopus)


Excessive amounts of salt in food, as usually consumed worldwide, affect the vascular system, leading to high blood pressure and premature disabilities. Salt entering the vascular bed after a salty meal is transiently bound to the endothelial glycocalyx, a negatively charged biopolymer lining the inner surface of the blood vessels. This barrier protects the endothelium against salt overload. A poorly-developed glycocalyx increases the salt permeability of the vascular system and the amount of salt being deposited in the body, which affects organ function. A simple test system is now available that evaluates vascular salt sensitivity in humans and identifies individuals who are at risk of salt-induced hypertension. This short review aims to discuss how the underlying basic research can be translated into medical practice and, thus, meaningful health outcomes.

Original languageEnglish
Article number20
JournalF1000 Biology Reports
Issue number1
Publication statusPublished - 02.10.2012

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


Dive into the research topics of 'An emerging concept of vascular salt sensitivity'. Together they form a unique fingerprint.

Cite this