TY - JOUR
T1 - Aminoglycosides were associated with higher rates of surgical patent ductus arteriosus closure in preterm infants
AU - Marissen, Janina
AU - Erdmann, Harald
AU - Böckenholt, Kai
AU - Hoppenz, Marc
AU - Rausch, Tanja K.
AU - Härtel, Christoph
AU - Herting, Egbert
AU - Göpel, Wolfgang
N1 - Publisher Copyright:
© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8/18
Y1 - 2020/8/18
N2 - Aim: In animal studies, aminoglycosides induced ductus arteriosus relaxation in a dose-dependent fashion. We tested the hypothesis that antibiotic treatment of preterm infants with aminoglycosides is associated with higher rates of surgical patent ductus arteriosus (PDA) closure. Methods: Preterm infants (birthweight <1000 grams or gestational age <29 weeks) enrolled in 62 German neonatal intensive care units (NICUs) were analysed. NICUs were stratified according to the use of aminoglycosides as first-line antibiotics. Results: Baseline data were not different when NICUs using aminoglycosides (n = 9965 infants) were compared to NICUs using other antibiotics (n = 1948 infants). Rates of surgical PDA closure were 5.9% for NICUs using aminoglycosides; 6.2% for units using gentamicin; and 5.0% for NICUs using tobramycin compared to 4.1% in NICUs using other antibiotics (P <.001, P <.001 and P =.140, respectively, Fisher's exact test). Indomethacin and ibuprofen use was more common in NICUs using aminoglycosides (41% vs 33%, P <.001, Fisher's exact test). Gentamicin trough levels were higher in NICUs with surgical closure rates above the mean (median 2.0 µg/mL, inter-quartile range 0.8-4.0 µg/mL vs 1.2 µg/mL, IQR 0.8-1.7, P <.001, Mann-Whitney U test). Conclusion: First-line antibiotic treatment of preterm infants with aminoglycosides was associated with higher rates of surgical PDA closure.
AB - Aim: In animal studies, aminoglycosides induced ductus arteriosus relaxation in a dose-dependent fashion. We tested the hypothesis that antibiotic treatment of preterm infants with aminoglycosides is associated with higher rates of surgical patent ductus arteriosus (PDA) closure. Methods: Preterm infants (birthweight <1000 grams or gestational age <29 weeks) enrolled in 62 German neonatal intensive care units (NICUs) were analysed. NICUs were stratified according to the use of aminoglycosides as first-line antibiotics. Results: Baseline data were not different when NICUs using aminoglycosides (n = 9965 infants) were compared to NICUs using other antibiotics (n = 1948 infants). Rates of surgical PDA closure were 5.9% for NICUs using aminoglycosides; 6.2% for units using gentamicin; and 5.0% for NICUs using tobramycin compared to 4.1% in NICUs using other antibiotics (P <.001, P <.001 and P =.140, respectively, Fisher's exact test). Indomethacin and ibuprofen use was more common in NICUs using aminoglycosides (41% vs 33%, P <.001, Fisher's exact test). Gentamicin trough levels were higher in NICUs with surgical closure rates above the mean (median 2.0 µg/mL, inter-quartile range 0.8-4.0 µg/mL vs 1.2 µg/mL, IQR 0.8-1.7, P <.001, Mann-Whitney U test). Conclusion: First-line antibiotic treatment of preterm infants with aminoglycosides was associated with higher rates of surgical PDA closure.
UR - http://www.scopus.com/inward/record.url?scp=85090207445&partnerID=8YFLogxK
U2 - 10.1111/apa.15541
DO - 10.1111/apa.15541
M3 - Journal articles
C2 - 32810301
AN - SCOPUS:85090207445
SN - 0803-5253
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
ER -