TY - JOUR
T1 - Ameroid rings for gradual chronic constriction of the sciatic nerve in rats: Contribution of different nerves to neuropathic pain
AU - Tzabazis, A.
AU - Kim, P. H.
AU - Sweitzer, S. M.
AU - Yeomans, D. C.
N1 - Funding Information:
This work was supported by Public Health Service Grant DA08256 (D.C.Y.).
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2004/8/30
Y1 - 2004/8/30
N2 - Mononeuropathy was induced by placing an ameroid ring around the sciatic nerve and was compared with chronic constriction injury (CCI) of the sciatic nerve [Pain 33 (1988) 87] in rats. Mechanical allodynia was assessed and the role of sciatic and saphenous afferents (Aδ and C) in thermal hyperalgesia investigated. A shorter duration of mechanical allodynia in ameroid rats as compared to CCI rats was observed. Thermal hyperalgesia was observed in the saphenous innervated skin of the hindpaw for Aδ and C nociceptors in ameroid and for Aδ nociceptors only in CCI rats, respectively. The sciatic innervated skin showed a thermal hypoalgesia with a fast onset for Aδ afferents and a slower onset for C afferents in CCI and ameroid rats. The duration of both thermal hypo- and hyperalgesia was longer in ameroid rats. We conclude that ameroid rings are a useful tool for the investigation of long-duration hyperalgesic effects of nerve injury, as the effects were more stable and seen for a longer time (>8 weeks) as compared to the CCI model. The uninjured saphenous afferents, in particular C fibers, mediate thermal hyperalgesia after chronic constriction of the sciatic nerve using an ameroid ring.
AB - Mononeuropathy was induced by placing an ameroid ring around the sciatic nerve and was compared with chronic constriction injury (CCI) of the sciatic nerve [Pain 33 (1988) 87] in rats. Mechanical allodynia was assessed and the role of sciatic and saphenous afferents (Aδ and C) in thermal hyperalgesia investigated. A shorter duration of mechanical allodynia in ameroid rats as compared to CCI rats was observed. Thermal hyperalgesia was observed in the saphenous innervated skin of the hindpaw for Aδ and C nociceptors in ameroid and for Aδ nociceptors only in CCI rats, respectively. The sciatic innervated skin showed a thermal hypoalgesia with a fast onset for Aδ afferents and a slower onset for C afferents in CCI and ameroid rats. The duration of both thermal hypo- and hyperalgesia was longer in ameroid rats. We conclude that ameroid rings are a useful tool for the investigation of long-duration hyperalgesic effects of nerve injury, as the effects were more stable and seen for a longer time (>8 weeks) as compared to the CCI model. The uninjured saphenous afferents, in particular C fibers, mediate thermal hyperalgesia after chronic constriction of the sciatic nerve using an ameroid ring.
UR - http://www.scopus.com/inward/record.url?scp=4444238756&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2004.05.006
DO - 10.1016/j.brainresbull.2004.05.006
M3 - Journal articles
C2 - 15342099
AN - SCOPUS:4444238756
SN - 0361-9230
VL - 64
SP - 127
EP - 132
JO - Brain research bulletin
JF - Brain research bulletin
IS - 2
ER -
