Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection

Jan Rupp; Daniel Droemann; Torsten Goldmann; Peter Zabel; Werner Solbach; Ekkehard Vollmer; Detlev Branscheid; Klaus Dalhoff; Matthias Maass

doi:10.1016/j.femsim.2004.03.004

Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection

Jan Rupp^*, Daniel Droemann, Torsten Goldmann, Peter Zabel, Werner Solbach, Ekkehard Vollmer, Detlev Branscheid, Klaus Dalhoff, Matthias Maass

^*Corresponding author for this work

29 Citations (Scopus)

Abstract

Pulmonary presence of Chlamydia pneumoniae is associated with acute and chronic infections. We show that unapparent chlamydial infection in four out of 31 chronic obstructive pulmonary disease (COPD) patients (12.9%) is characterized by a significant increase in infected alveolar epithelial cells type II (18.2±3.5% vs. 2.3±0.9; IHC/ISH) compared to a newly established model of acute chlamydial infection (ACIM) in vital lung specimens from pulmonary lobectomy. Expression of cHSP60 demonstrated pathogen viability and virulence in the ACIM. We conclude that target cells differ in acute and chronic chlamydial infection and suggest the ACIM as a novel tool to analyze the host-pathogen-interactions in acute respiratory infections.

Original language	English
Journal	FEMS Immunology and Medical Microbiology
Volume	41
Issue number	3
Pages (from-to)	197-203
Number of pages	7
ISSN	0928-8244
DOIs	https://doi.org/10.1016/j.femsim.2004.03.004
Publication status	Published - 01.07.2004

Funding

This study was supported in part by a grant from the Deutsche Forschungsgemeinschaft (SFB 367, B11 and SPP1130, Ma2070/4-1) and the BMBF (CAPNetz, Projects A6 and B2). We gratefully thank T. Luedemann (Luebeck), S. Adrian, H. Kuehl and W. Martens (Borstel) for technical assistance.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/j.femsim.2004.03.004

Cite this

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title = "Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection",

abstract = "Pulmonary presence of Chlamydia pneumoniae is associated with acute and chronic infections. We show that unapparent chlamydial infection in four out of 31 chronic obstructive pulmonary disease (COPD) patients (12.9\%) is characterized by a significant increase in infected alveolar epithelial cells type II (18.2±3.5\% vs. 2.3±0.9; IHC/ISH) compared to a newly established model of acute chlamydial infection (ACIM) in vital lung specimens from pulmonary lobectomy. Expression of cHSP60 demonstrated pathogen viability and virulence in the ACIM. We conclude that target cells differ in acute and chronic chlamydial infection and suggest the ACIM as a novel tool to analyze the host-pathogen-interactions in acute respiratory infections.",

author = "Jan Rupp and Daniel Droemann and Torsten Goldmann and Peter Zabel and Werner Solbach and Ekkehard Vollmer and Detlev Branscheid and Klaus Dalhoff and Matthias Maass",

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T1 - Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection

AU - Rupp, Jan

AU - Droemann, Daniel

AU - Goldmann, Torsten

AU - Zabel, Peter

AU - Solbach, Werner

AU - Vollmer, Ekkehard

AU - Branscheid, Detlev

AU - Dalhoff, Klaus

AU - Maass, Matthias

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Pulmonary presence of Chlamydia pneumoniae is associated with acute and chronic infections. We show that unapparent chlamydial infection in four out of 31 chronic obstructive pulmonary disease (COPD) patients (12.9%) is characterized by a significant increase in infected alveolar epithelial cells type II (18.2±3.5% vs. 2.3±0.9; IHC/ISH) compared to a newly established model of acute chlamydial infection (ACIM) in vital lung specimens from pulmonary lobectomy. Expression of cHSP60 demonstrated pathogen viability and virulence in the ACIM. We conclude that target cells differ in acute and chronic chlamydial infection and suggest the ACIM as a novel tool to analyze the host-pathogen-interactions in acute respiratory infections.

AB - Pulmonary presence of Chlamydia pneumoniae is associated with acute and chronic infections. We show that unapparent chlamydial infection in four out of 31 chronic obstructive pulmonary disease (COPD) patients (12.9%) is characterized by a significant increase in infected alveolar epithelial cells type II (18.2±3.5% vs. 2.3±0.9; IHC/ISH) compared to a newly established model of acute chlamydial infection (ACIM) in vital lung specimens from pulmonary lobectomy. Expression of cHSP60 demonstrated pathogen viability and virulence in the ACIM. We conclude that target cells differ in acute and chronic chlamydial infection and suggest the ACIM as a novel tool to analyze the host-pathogen-interactions in acute respiratory infections.

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M3 - Journal articles

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JO - FEMS Immunology and Medical Microbiology

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ER -

Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection

Abstract

Funding

UN SDGs

Research Areas and Centers

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