Altered temporal dynamics of neural adaptation in the aging human auditory cortex

Björn Herrmann; Molly J. Henry; Ingrid S. Johnsrude; Jonas Obleser

doi:10.1016/j.neurobiolaging.2016.05.006

Altered temporal dynamics of neural adaptation in the aging human auditory cortex

Björn Herrmann^*, Molly J. Henry, Ingrid S. Johnsrude, Jonas Obleser

^*Corresponding author for this work

Department of Psychology

42 Citations (Scopus)

Abstract

Neural response adaptation plays an important role in perception and cognition. Here, we used electroencephalography to investigate how aging affects the temporal dynamics of neural adaptation in human auditory cortex. Younger (18-31 years) and older (51-70 years) normal hearing adults listened to tone sequences with varying onset-to-onset intervals. Our results show long-lasting neural adaptation such that the response to a particular tone is a nonlinear function of the extended temporal history of sound events. Most important, aging is associated with multiple changes in auditory cortex; older adults exhibit larger and less variable response magnitudes, a larger dynamic response range, and a reduced sensitivity to temporal context. Computational modeling suggests that reduced adaptation recovery times underlie these changes in the aging auditory cortex and that the extended temporal stimulation has less influence on the neural response to the current sound in older compared with younger individuals. Our human electroencephalography results critically narrow the gap to animal electrophysiology work suggesting a compensatory release from cortical inhibition accompanying hearing loss and aging.

Original language	English
Journal	Neurobiology of Aging
Volume	45
Pages (from-to)	10-22
Number of pages	13
ISSN	0197-4580
DOIs	https://doi.org/10.1016/j.neurobiolaging.2016.05.006
Publication status	Published - 01.09.2016

Funding

The authors thank Heike Boethel for her support during data collection. Research was supported by the Max Planck Society (Max Planck Research Group grant to Jonas Obleser), the Canadian Institutes of Health Research ( MOP133450 to Ingrid S. Johnsrude), and the Brain and Mind Institute at the University of Western Ontario (postdoctoral fellowship awards to Björn Herrmann & Molly J. Henry). The authors thank 2 anonymous reviewers for their helpful comments.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 5 Gender Equality
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.neurobiolaging.2016.05.006

Cite this

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Altered temporal dynamics of neural adaptation in the aging human auditory cortex

Abstract

Funding

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Research Areas and Centers

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